ZXDC information

ZXDC
Identifiers
Aliases	ZXDC, ZXDL, ZXD family zinc finger C
External IDs	OMIM: 615746 MGI: 1933108 HomoloGene: 82340 GeneCards: ZXDC
Gene location (Human)
Chr.	Chromosome 3 (human)
End	126,475,891 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	90,380,472 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right lobe of liver; ; sural nerve; ; ganglionic eminence; ; right uterine tube; ; body of pancreas; ; gastric mucosa; ; monocyte; ; blood; ; skin of abdomen;
	Top expressed in
	ascending aorta; ; aortic valve; ; placenta; ; secondary oocyte; ; Paneth cell; ; retinal pigment epithelium; ; conjunctival fornix; ; renal corpuscle; ; supraoptic nucleus; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; LRR domain binding; C2H2 zinc finger domain binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cellular component;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	79364
	80292
	ENSG00000070476
	ENSMUSG00000034430
	Q2QGD7
	Q8C8V1
	NM_001040653; NM_025112
	NM_030260; NM_173002
	NP_001035743; NP_079388
	NP_084536; NP_766590
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II.^[5] For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein.^[6] ZXDC is activated by sumoylation, a post-translational modification.^[7] ZXDC plays a role in controlling immunological responses, cancer formation and progression, and cell proliferation, differentiation, and survival.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070476 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034430 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Al-Kandari W, Jambunathan S, Navalgund V, Koneni R, Freer M, Parimi N, et al. (January 2007). "ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription". Molecular Immunology. 44 (4): 311–321. doi:10.1016/j.molimm.2006.02.029. PMC 1624858. PMID 16600381.
^ Al-Kandari W, Koneni R, Navalgund V, Aleksandrova A, Jambunathan S, Fontes JD (June 2007). "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription". Journal of Molecular Biology. 369 (5): 1175–1187. doi:10.1016/j.jmb.2007.04.033. PMC 1963517. PMID 17493635.
^ Jambunathan S, Fontes JD (September 2007). "Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain". Biological Chemistry. 388 (9): 965–972. doi:10.1515/BC.2007.106. PMID 17696781. S2CID 1007656.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070476 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034430 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Al-Kandari W, Jambunathan S, Navalgund V, Koneni R, Freer M, Parimi N, et al. (January 2007). "ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription". Molecular Immunology. 44 (4): 311–321. doi:10.1016/j.molimm.2006.02.029. PMC 1624858. PMID 16600381.

[6] Al-Kandari W, Koneni R, Navalgund V, Aleksandrova A, Jambunathan S, Fontes JD (June 2007). "The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription". Journal of Molecular Biology. 369 (5): 1175–1187. doi:10.1016/j.jmb.2007.04.033. PMC 1963517. PMID 17493635.

[7] Jambunathan S, Fontes JD (September 2007). "Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain". Biological Chemistry. 388 (9): 965–972. doi:10.1515/BC.2007.106. PMID 17696781. S2CID 1007656.

ZXDC information

and 3 Related for: ZXDC information

ZXDC

List of human transcription factors

CIITA