Nuclear receptor coactivator 1 information

NCOA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FM6, 1FM9, 1K74, 1K7L, 1KV6, 1K4W, 1N4H, 1NQ7, 1NRL, 1P8D, 1PZL, 1RDT, 1TFC, 1U3R, 1U3S, 1X76, 1XIU, 1XV9, 1XVP, 1YY4, 1ZAF, 2A3I, 2C52, 2FVJ, 2GTK, 2HBH, 2HC4, 2HCD, 2HFP, 2NPA, 2NV7, 2P54, 2PRG, 3BEJ, 3BQD, 3CTB, 3CWD, 3DCT, 3DCU, 3DR1, 3ET1, 3ET3, 3FEI, 3FEJ, 3FUR, 3FXV, 3G8I, 3G9E, 3GYT, 3GYU, 3H0A, 3HC5, 3HC6, 3HVL, 3IPQ, 3IPS, 3IPU, 3KMR, 3LMP, 3OKH, 3OKI, 3OLF, 3OLL, 3OLS, 3OMK, 3OMM, 3OMO, 3OMP, 3OMQ, 3OOF, 3OOK, 3P88, 3P89, 3QT0, 3RUT, 3RUU, 3RVF, 3S9S, 3T03, 3UU7, 3UUA, 3UUD, 3V9Y, 3VN2, 4DK7, 4DK8, 4DM6, 4DM8, 4DQM, 4F9M, 4FGY, 4G1D, 4G1Y, 4G1Z, 4G20, 4G21, 4G2H, 4HEE, 4J5X, 4JYG, 4JYH, 4JYI, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4TUZ, 4TV1, 5AVI, 5AVL, 4Y29, 4RUJ, 4RUP, 5A86, 5E7V, 4UDB, 4UDA, 5AZT, 5HJS
Identifiers
Aliases	NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74, nuclear receptor coactivator 1
External IDs	OMIM: 602691 MGI: 1276523 HomoloGene: 7859 GeneCards: NCOA1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,770,702 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,477,182 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; middle frontal gyrus; ; Brodmann area 23; ; entorhinal cortex; ; tibialis anterior muscle; ; postcentral gyrus; ; frontal pole; ; endothelial cell; ; Region I of hippocampus proper; ; Achilles tendon;
	Top expressed in
	retinal pigment epithelium; ; lateral geniculate nucleus; ; motor neuron; ; ventromedial nucleus; ; mammillary body; ; subiculum; ; ciliary body; ; pineal gland; ; nucleus accumbens; ; lacrimal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; transcription coactivator activity; protein dimerization activity; protein N-terminus binding; transcription factor binding; chromatin binding; histone acetyltransferase activity; protein binding; androgen receptor binding; enzyme binding; acyltransferase activity; nuclear receptor coactivator activity; aryl hydrocarbon receptor binding; nuclear receptor binding; estrogen receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; progesterone receptor binding; retinoic acid receptor binding; protein-containing complex binding; retinoid X receptor binding;
Cellular component	nucleus; nucleoplasm; cytosol; plasma membrane; protein-containing complex; cytoplasm; neuron projection;
Biological process	androgen receptor signaling pathway; regulation of RNA biosynthetic process; regulation of transcription, DNA-templated; cellular response to Thyroglobulin triiodothyronine; regulation of cellular response to drug; transcription, DNA-templated; positive regulation of transcription, DNA-templated; labyrinthine layer morphogenesis; positive regulation of neuron differentiation; bile acid and bile salt transport; positive regulation of apoptotic process; histone H4 acetylation; regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; intracellular receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter by galactose; regulation of lipid metabolic process; transcription by RNA polymerase II; cellular response to hormone stimulus; lactation; male gonad development; response to hormone; cerebellum development; hippocampus development; hypothalamus development; cerebral cortex development; response to estradiol; response to retinoic acid; response to progesterone; estrous cycle; positive regulation of female receptivity; male mating behavior;
	Sources:Amigo / QuickGO
Orthologs
	8648
	17977
	ENSG00000084676
	ENSMUSG00000020647
	Q15788
	P70365
NM_003743; NM_147223; NM_147233; NM_001362950; NM_001362952;
	NM_001362954; NM_001362955
	NM_010881
NP_003734; NP_671756; NP_671766; NP_001349879; NP_001349881;
	NP_001349883; NP_001349884
	NP_035011
	Wikidata
View/Edit Human	View/Edit Mouse

The nuclear receptor coactivator 1 (NCOA1), also called steroid receptor coactivator-1 (SRC-1), is a transcriptional coregulatory protein that contains several nuclear receptor–interacting domains and possesses intrinsic histone acetyltransferase activity.^[5]^[6] It is encoded by the gene NCOA1.^[7]

NCOA1 is recruited to DNA promoter sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression as a coactivator.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000084676 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020647 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–1357. Bibcode:1995Sci...270.1354O. doi:10.1126/science.270.5240.1354. PMID 7481822. S2CID 28749162.
^ ^a ^b Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". Journal of Biological Chemistry. 273 (20): 12101–12108. doi:10.1074/jbc.273.20.12101. PMID 9575154.
^ "NCOA1 Gene - Nuclear Receptor Coactivator 1". GeneCards: The Human Gene Database. 4 October 2023. Retrieved 22 November 2023.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084676 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020647 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Onate_1995-5] Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–1357. Bibcode:1995Sci...270.1354O. doi:10.1126/science.270.5240.1354. PMID 7481822. S2CID 28749162.

[Onate_1998-6] Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". Journal of Biological Chemistry. 273 (20): 12101–12108. doi:10.1074/jbc.273.20.12101. PMID 9575154.

[7] "NCOA1 Gene - Nuclear Receptor Coactivator 1". GeneCards: The Human Gene Database. 4 October 2023. Retrieved 22 November 2023.

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