CDK7 is a cyclin-dependent kinase shown to be not easily classified. CDK7 is both a CDK-activating kinase (CAK) and a component of the general transcription factor TFIIH.
in a pathway to ensure that each cell accurately replicates its DNA and segregates it equally between the two daughter cells. One CDK–the CDK7 complex–cannot...
GTF2H5/TTDA) form the core complex. The cyclin-activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein. Two of the...
increasingly adopted by the community of scientists working on the mTOR pathway to refer to the protein and in homage to the original discovery of the...
base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged...
physically interact with Rheb. Thus the amino acid pathway as well as the growth factor/energy pathway converge on endosomes and lysosomes. Thus the Ragulator-Rag...
protects against viral infections. It also has a role in several signaling pathways. Protein kinase-R is activated by double-stranded RNA (dsRNA), introduced...
serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling...
complex. TFIIH is a large protein complex that contains among others the CDK7/cyclin H kinase complex and a DNA helicase. TFIIH has three functions: It...
and apoptosis. The duration and intensity of signals determine which pathway ensues. Additionally, the use of protein scaffolds helps to place the MAPKKK...
involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling...
2018). "Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models". Cell. 175 (1): 171–185.e25. doi:10...
molecules released by signaling pathways during pathogenic attack. IRAK-1 is classified as a kinase enzyme, which regulates pathways in both innate and adaptive...
phototropins are hit with blue light, they induce a signal transduction pathway that alters the plant cells' functions in different ways. Phototropins...
and trichothiodystrophy. XPB has been shown to interact with: BCR gene, CDK7, ERCC2, GTF2H1, GTF2H2, GTF2H4, GTF2H5, P53, PSMC5, and XPC. Potent, bioactive...
of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in the IKBKG gene results in incontinentia pigmenti, hypohidrotic...
which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation...
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