negative regulation of transcription by RNA polymerase II
protein export from nucleus
regulation of protein catabolic process
protein localization to nucleus
protein transport
ribosomal large subunit export from nucleus
intracellular protein transport
viral process
sister chromatid cohesion
ribosomal subunit export from nucleus
regulation of protein export from nucleus
ribosome biogenesis
transport
nucleocytoplasmic transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7514
103573
Ensembl
ENSG00000082898
ENSMUSG00000020290
UniProt
O14980
Q6P5F9
RefSeq (mRNA)
NM_003400
NM_001035226 NM_134014
RefSeq (protein)
NP_003391
NP_001030303 NP_598775
Location (UCSC)
Chr 2: 61.48 – 61.54 Mb
Chr 11: 23.21 – 23.25 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.
^ abcGRCh38: Ensembl release 89: ENSG00000082898 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020290 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins...
(SINEs), selinexor works by binding to exportin 1 (also known as XPO1 or CRM1). XPO1 is a karyopherin which performs nuclear transport of several proteins...
trial for multiple myeloma. In this trial, patients were treated with the XPO1 inhibitor selinexor. DarwinHealth scientists identified a Linear Discriminant...
nuclear export (SINEs or SINE compounds) are drugs that block exportin 1 (XPO1 or CRM1), a protein involved in transport from the cell nucleus to the cytoplasm...
alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1 (XPO1), a protein required for nuclear export of proteins containing a nuclear...
exportin-1 (XPO1/CRM1) and Ran-GTP. Rev recruits this export machinery via a nuclear export sequence (NES) present in Rev. This Rev-RRE-Xpo1/RanGTP complex...
Nucleoporin 62 has been shown to interact with: HSF2, KPNB1, NUTF2, TRAF3, and XPO1, Nup93. GRCh38: Ensembl release 89: ENSG00000213024 – Ensembl, May 2017 GRCm38:...
other elements may also play a role. This form of export relies on the CRM1/XPO1 pathway. Nuclear eIF4E has been shown to play other roles in RNA processing...
predicted interacting proteins found in Y2H screens, such as exportin 1 (XPO1), ras homolog family member U (RHOU), deoxyhypusine hydroxylase/monooxygenase...
guanine nucleotide release from RAN. RANBP1 has been shown to interact with XPO1, KPNB1 and Ran. GRCh38: Ensembl release 89: ENSG00000099901 – Ensembl, May...
humans is encoded by the NMD3 gene. NMD3 has been shown to interact with XPO1. GRCh38: Ensembl release 89: ENSG00000169251 – Ensembl, May 2017 GRCm38:...
have been characterized. RANBP3 has been shown to interact with RCC1 and XPO1. GRCh38: Ensembl release 89: ENSG00000031823 – Ensembl, May 2017 GRCm38:...
protein-tyrosine kinases through its SH2 domain and regulates their kinase activity Xpo1 Exportin-1 association 0.35 Pull down Mediates the nuclear export of cellular...
Global Information
