Protein arginine N-methyltransferase-4 (PRMT4/CARM1)[1][2][3] methylation of arginine residues within proteins plays a critical key role in transcriptional regulation (see the PRMT4 pathway on the left). PRMT4 binds to the classes of transcriptional activators known as p160 and CBP/p300.[4] The modified forms of these proteins are involved in stimulation of gene expression via steroid hormone receptors. Significantly, PRMT4 methylates core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. PRMT4 recruitment of chromatin by binding to coactivators increases histone methylation and enhances the accessibility of promoter regions for transcription. Methylation of the transcriptional coactivator CBP by PRMT4 inhibits binding to CREB and thereby partitions the limited cellular pool of CBP for steroid hormone receptor interaction.
^Chen, D., Ma, H., Hong, H., Koh, S. S., Huang, S. M., Schurter, B. T., Aswad, D. W., and Stallcup, M. R. (1999) Science 284, 2174-2177
^Chen, D., Huang, S. M., and Stallcup, M. R. (2000) J. Biol. Chem. 275, 40810-40816
^Koh, S., Chen, D., Lee, Y.-H., and Stallcup, M. R. (2001) J. Biol. Chem. 276, 1089-1091
^Zika E, et al., Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16321-6
N-methyltransferase-4 (PRMT4/CARM1) methylation of arginine residues within proteins plays a critical key role in transcriptional regulation (see the PRMT4pathway on the...
endpoints in a 2018 Phase III AML trial. Methyltransferase DNA methylation PRMT4pathway Cell cycle regulated Methyltransferase Iyer LM, Zhang D, Aravind L (January...
(R248) negatively regulates MDH1. Protein arginine methyltransferase 4 (PRMT4/CARM1) methylates and inhibits MDH1 by disrupting its dimerization. Arginine...
GluN2A and PRMT8 leads to hypersensitivity to pain. In terms of PRMT4, the knockout of PRMT4 has shown to decrease pain hypersensitivity, but it is not clear...
arginine methyltransferases (PRMTs): Type I PRMTs (PRMT1, PRMT2, PRMT3, PRMT4, PRMT6, and PRMT8) attach two methyl groups to a single terminal nitrogen...
residues on histone tails. The first type of PRMTs (PRMT1, PRMT3, CARM1⧸PRMT4, and Rmt1⧸Hmt1) produce monomethylarginine and asymmetric dimethylarginine...