cysteine-type endopeptidase inhibitor activity involved in apoptotic process
identical protein binding
Cellular component
cytoplasm
cytosol
intracellular anatomical structure
IPAF inflammasome complex
nucleus
Biological process
pyroptosis
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
immune system process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
mitotic spindle assembly
regulation of signal transduction
defense response to bacterium
positive regulation of NF-kappaB transcription factor activity
detection of bacterium
activation of innate immune response
positive regulation of apoptotic process
inflammatory response
protein homooligomerization
activation of cysteine-type endopeptidase activity involved in apoptotic process
apoptotic process
protein ubiquitination
regulation of apoptotic process
innate immune response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
58484
268973
Ensembl
ENSG00000091106
ENSMUSG00000039193
UniProt
Q9NPP4
Q3UP24
RefSeq (mRNA)
NM_001199138 NM_001199139 NM_001302504 NM_021209
NM_001033367
RefSeq (protein)
NP_001186067 NP_001186068 NP_001289433 NP_067032
NP_001028539
Location (UCSC)
Chr 2: 32.22 – 32.27 Mb
Chr 17: 74.73 – 74.77 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000091106 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039193 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J (Jun 2001). "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis". Biochemical and Biophysical Research Communications. 284 (1): 77–82. doi:10.1006/bbrc.2001.4928. PMID 11374873.
domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. The NLRC4 protein is highly conserved across mammalian species. It bears homology...
of which are also driven by NLRs—NLRP3 (NLR family PYD-containing 3) and NLRC4 (NLR family CARD-containing 4). The physiological relevance of the inflammasome...
DAMPs are recognised by certain endogenous PRRs. For example, NLR proteins NLRC4 can recognise flagellin and type III secretion system components. NLRP3...
canonical pathway and is activated by canonical inflammasomes such as NLRP3 and NLRC4 inflammasomes, which are multi-protein complexes that are formed upon recognition...
infection. Resident macrophages can also recognize flagellin and activate NLRC4 inflammasome complex to activate caspase-1 and IL-1β and IL-18 release....
(ASC) and Nod-Like Receptor (NLR) Family CARD Domain-Containing Protein 4 (NLRC4) through CARD-CARD interactions in the formation of inflammasomes. Caspase-1...
disease, Yao Syndrome and Blau syndrome. NOD2 has been shown to interact with NLRC4. NOD2 has also been shown to bind to MAVS in response to ssRNA or viral...
C. E. (6 May 2014). "Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex". Proceedings of the National...
PRRs that are known to induce inflammasome formation are NLRP3, NLRP1, NLRC4, AIM2 and Pyrin. These proteins contain oligomerization NACHT domains, CARD...
flagellin or the dsDNA analog Poly(dA:dT) to activate inflammasomes such as NLRC4 and AIM 2 respectively. When Dapansutrile was added they found no difference...
unequivocal genetic evidence by identifying the NOD-like receptors NLRP3 and NLRC4 as proximal components of inflammasomes responsible for caspase-1 activation...
"Discovery and characterization of small molecule inhibitors of NLRP3 and NLRC4 inflammasomes". Journal of Biological Chemistry. 296: 100597. doi:10.1016/j...
Global Information
