BRD4 information

BRD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I8N, 2LSP, 2MJV, 2OSS, 2OUO, 2YEL, 2YEM, 3MXF, 3P5O, 3SVF, 3SVG, 3U5J, 3U5K, 3U5L, 3UVW, 3UVX, 3UVY, 3UW9, 3ZYU, 4A9L, 4BJX, 4BW1, 4BW2, 4BW3, 4BW4, 4C66, 4C67, 4CFK, 4CFL, 4CL9, 4CLB, 4DON, 4E96, 4F3I, 4GPJ, 4HBV, 4HBW, 4HBX, 4HBY, 4HXK, 4HXL, 4HXM, 4HXN, 4HXO, 4HXP, 4HXR, 4HXS, 4IOO, 4IOQ, 4IOR, 4J0R, 4J0S, 4J3I, 4KV1, 4KV4, 4LR6, 4LRG, 4LYI, 4LYS, 4LYW, 4LZR, 4LZS, 4MEN, 4MEO, 4MEP, 4MEQ, 4MR3, 4MR4, 4NQM, 4NR8, 4NUC, 4NUD, 4NUE, 4O70, 4O71, 4O72, 4O74, 4O75, 4O76, 4O77, 4O78, 4O7A, 4O7B, 4O7C, 4O7E, 4O7F, 4OGI, 4OGJ, 4PCE, 4PCI, 4PS5, 4QB3, 4QR3, 4QR4, 4QR5, 4QZS, 4UIX, 4UIZ, 4UYD, 4WIV, 4XY9, 4XYA, 4Z1Q, 4Z1S, 4Z93, 5A5S, 5A85, 5BT4, 5D3T, 5D3S, 5D3H, 5D3J, 5CTL, 4WHW, 5D3R, 4X2I, 5CPE, 5CRZ, 4YH3, 4ZC9, 5EI4, 5D3P, 5CQT, 5D3L, 5EIS, 5CRM, 5D0C, 5EGU, 5CP5, 5D25, 5CY9, 5COI, 5D26, 4YH4, 5CS8, 5ACY, 5DX4, 5D24, 5HM0, 5HLS, 2N3K, 5JWM, 5DLX, 2NCZ, 2NNU, 5DW2, 2ND1, 4ZW1, 5CFW, 2ND0, 5DLZ
Identifiers
Aliases	BRD4, CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
External IDs	OMIM: 608749; MGI: 1888520; HomoloGene: 137685; GeneCards: BRD4; OMA:BRD4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,332,545 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,284,722 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sural nerve; ; tendon of biceps brachii; ; nipple; ; internal globus pallidus; ; pylorus; ; secondary oocyte; ; cardia; ; renal medulla; ; vena cava;
	Top expressed in
	Rostral migratory stream; ; genital tubercle; ; tail of embryo; ; cumulus cell; ; blood; ; zygote; ; internal carotid artery; ; ascending aorta; ; secondary oocyte; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	p53 binding; chromatin binding; protein binding; lysine-acetylated histone binding; RNA polymerase II complex binding; RNA polymerase II CTD heptapeptide repeat kinase activity; enzyme binding; RNA polymerase II C-terminal domain binding; P-TEFb complex binding;
Cellular component	nucleoplasm; chromosome; condensed nuclear chromosome; nucleus; cytosol;
Biological process	chromatin remodeling; regulation of transcription, DNA-templated; negative regulation of DNA damage checkpoint; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription, DNA-templated; cellular response to DNA damage stimulus; regulation of inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of G2/M transition of mitotic cell cycle; regulation of phosphorylation of RNA polymerase II C-terminal domain; viral process; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; chromatin organization; protein phosphorylation; positive regulation of transcription, DNA-templated; positive regulation of histone H3-K36 trimethylation;
	Sources:Amigo / QuickGO
Orthologs
	23476
	57261
	ENSG00000141867
	ENSMUSG00000024002
	O60885
	Q9ESU6
	NM_014299; NM_058243; NM_001330384; NM_001379291; NM_001379292
	NM_001286630; NM_020508; NM_198094
	NP_001317313; NP_055114; NP_490597; NP_001366220; NP_001366221
	NP_001273559; NP_065254; NP_932762
	Wikidata
View/Edit Human	View/Edit Mouse

Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene.^[5]^[6]

BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT.^[7] BRD4, similar to other BET family members, contains two bromodomains that recognize acetylated lysine residues.^[8] BRD4 also has an extended C-terminal domain with little sequence homology to other BET family members.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024002 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K (Sep 2000). "A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition". Molecular and Cellular Biology. 20 (17): 6537–49. doi:10.1128/MCB.20.17.6537-6549.2000. PMC 86127. PMID 10938129.
^ "Entrez Gene: BRD4 bromodomain containing 4".
^ ^a ^b Zeng L, Zhou MM (Feb 2002). "Bromodomain: an acetyl-lysine binding domain". FEBS Letters. 513 (1): 124–8. doi:10.1016/s0014-5793(01)03309-9. PMID 11911891. S2CID 29706103.
^ Shi J, Vakoc CR (Jun 2014). "The mechanisms behind the therapeutic activity of BET bromodomain inhibition". Molecular Cell. 54 (5): 728–736. doi:10.1016/j.molcel.2014.05.016. PMC 4236231. PMID 24905006.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141867 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024002 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10938129-5] Dey A, Ellenberg J, Farina A, Coleman AE, Maruyama T, Sciortino S, Lippincott-Schwartz J, Ozato K (Sep 2000). "A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition". Molecular and Cellular Biology. 20 (17): 6537–49. doi:10.1128/MCB.20.17.6537-6549.2000. PMC 86127. PMID 10938129.

[entrez-6] "Entrez Gene: BRD4 bromodomain containing 4".

[ReferenceA-7] Zeng L, Zhou MM (Feb 2002). "Bromodomain: an acetyl-lysine binding domain". FEBS Letters. 513 (1): 124–8. doi:10.1016/s0014-5793(01)03309-9. PMID 11911891. S2CID 29706103.

[8] Shi J, Vakoc CR (Jun 2014). "The mechanisms behind the therapeutic activity of BET bromodomain inhibition". Molecular Cell. 54 (5): 728–736. doi:10.1016/j.molcel.2014.05.016. PMC 4236231. PMID 24905006.

BRD4 information

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