Transcriptional amplification involves increases in global levels of mRNAs produced from expressed genes and may be either uniform across all expressed genes or variable from gene to gene.
In genetics, transcriptional amplification is the process in which the total amount of messenger RNA (mRNA) molecules from expressed genes is increased during disease, development, or in response to stimuli.
In eukaryotic cells, the transcribing activity of RNA Polymerase II results in mRNA production. Transcriptional amplification is specifically defined as the increase in per-cell abundance of this set of expressed mRNAs. Transcriptional amplification is caused by changes in the amount or activity of transcription-regulating proteins.
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In genetics, transcriptionalamplification is the process in which the total amount of messenger RNA (mRNA) molecules from expressed genes is increased...
and control amplification, it is crucial to take into consideration the starting target molecules concentration and their amplification rate prior to...
contain humic acids may inhibit PCR amplification and lead to inaccurate results. Allele-specific PCR or The amplification refractory mutation system (ARMS):...
interest, produced through reverse transcription, followed by PCR amplification of the cDNA copies (see RT-PCR). The amplified cDNA copies are then sequenced...
product of either natural or artificial amplification or replication events is called an amplicon. "Gene amplification - Latest research and news - Nature"...
include a step that amplifies the genetic material—that is, makes many copies of it. Such NATs are called nucleic acid amplification tests (NAATs). There...
In biology, a branched DNA assay is a signal amplification assay (as opposed to a target amplification assay) that is used to detect nucleic acid molecules...
product of an amplification reaction, amplicon is used interchangeably with common laboratory terms, such as "PCR product." Artificial amplification is used...
translational or transcriptional repression. Historically, RNAi was known by other names, including co-suppression, post-transcriptional gene silencing...
comparable the same test method (target amplification, probe specific amplification, or signal amplification) should be used each time a patient specimen...
The cluster of RNA polymerase II and various transcription factors is known as a basal transcriptional complex (BTC). The preinitiation complex (PIC)...
is a transcriptional co-activator and its proliferative and oncogenic activity is driven by its association with the TEAD family of transcription factors...
An additional ORF coding for a replication mechanism can be added to amplify antigen translation and therefore immune response, decreasing the amount...
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular...
; Wang, Y.; Smallwood, A.; Gambhir, S. S. (2001). "Two-step transcriptionalamplification as a method for imaging reporter gene expression using weak...
Polymerase chain reaction (PCR), ligase chain reaction (LCR), and transcription-mediated amplification (TMA) are examples. In March 2021, researchers reported evidence...
incorporate multiple transcriptional factors. Utilizing MS2, p65, and HSF1 proteins, dCas9-SAM system recruits various transcriptional factors working synergistically...
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