A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones. Bromodomains, as the "readers" of lysine acetylation, are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes.[2] Their affinity is higher for regions where multiple acetylation sites exist in proximity. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices each separated by loop regions of variable lengths that form a hydrophobic pocket that recognizes the acetyl lysine.[1][3]
^ abPDB: 1e6i; Owen DJ, Ornaghi P, Yang JC, Lowe N, Evans PR, Ballario P, Neuhaus D, Filetici P, Travers AA (November 2000). "The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p". EMBO J. 19 (22): 6141–9. doi:10.1093/emboj/19.22.6141. PMC 305837. PMID 11080160.
^Ntranos, Achilles; Casaccia, Patrizia (2016). "Bromodomains: Translating the words of lysine acetylation into myelin injury and repair". Neuroscience Letters. 625: 4–10. doi:10.1016/j.neulet.2015.10.015. PMC 4841751. PMID 26472704.
^Zeng L, Zhou MM (February 2002). "Bromodomain: an acetyl-lysine binding domain". FEBS Lett. 513 (1): 124–8. doi:10.1016/S0014-5793(01)03309-9. PMID 11911891. S2CID 29706103.
A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones...
BET inhibitors are a class of drugs that reversibly bind the bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and...
Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. BRD4 is a member of the BET (bromodomain and extra terminal domain)...
Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET)...
protein–protein interaction domains, such as the acetyllysine-binding bromodomain[citation needed]. Histone acetyltransferases can also acetylate non-histone...
include HAT domains approximately 160 residues in length and a conserved bromodomain that has been found to be an acetyl-lysine targeting motif. Gcn5 has...
Bromodomain testis-specific protein is a protein that in humans is encoded by the BRDT gene. It is a member of the Bromodomain and Extra-terminal motif...
Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. BRD9 contains a bromodomain. It is closely related to BRD7....
Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene. The protein encoded by this gene belongs...
thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein...
Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene. BRD7 has been shown to interact with IRF2 and HNRPUL1. BRD7...
Peregrin also known as bromodomain and PHD finger-containing protein 1 is a protein that in humans is encoded by the BRPF1 gene located on 3p26-p25. Peregrin...
behaviour of propellers Bromo- and Extra-Terminal domain (BET) family of Bromodomain-containing proteins Bet (letter), the second letter in many Semitic alphabets...
member of the SWI/SNF family, possessing a SANT domain instead of the bromodomain. The protein ISWI can interact with several proteins giving three different...
(June 2014). "The mechanisms behind the therapeutic activity of BET bromodomain inhibition". Molecular Cell. 54 (5): 728–36. doi:10.1016/j.molcel.2014...
much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation...
(August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–7. doi:10.1021/acschembio...
and temozolamide in patients with brain cancer. Proteins containing bromodomains recognize and bind acetylated lysine residues in histones, causing chromatin...
transcription factor transcription regulator protein BACH1 BRWD1: encoding bromodomain and WD repeat-containing protein 1 BTG3: encoding protein BTG3 C21orf58:...
Tyrosine-protein kinase, or Bromodomain adjacent to zinc finger domain, 1B (BAZ1B) is an enzyme that in humans is encoded by the BAZ1B gene. This gene...
MN, Faver JC, et al. (March 2021). "Discovery and characterization of bromodomain 2-specific inhibitors of BRDT". Proceedings of the National Academy of...
Bromodomain adjacent to zinc finger domain protein 2A is a protein that in humans is encoded by the BAZ2A gene. GRCh38: Ensembl release 89: ENSG00000076108...
origin of replication. E2 also utilizes a cellular protein known as Bromodomain-4 (Brd4) to tether the viral genome to cellular chromosomes. This tethering...
Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene. The protein encoded by this gene interacts with thyroid hormone...
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