Diazepam prodrug
Avizafone Routes of administration Intramuscular injection ATC code
(2S )-2,6-diamino-N -{[(2-benzoyl-4-chlorophenyl)methylcarbamoyl]methyl}hexanamide
CAS Number 65617-86-9 Y PubChem CID ChemSpider 64974 Y UNII ChEMBL ChEMBL2103985 N CompTox Dashboard (EPA ) DTXSID90215868 Formula C 22 H 27 Cl N 4 O 3 Molar mass 430.93 g·mol−1 3D model (JSmol)
Clc1cc(c(N(C(=O)CNC(=O)[C@@H](N)CCCCN)C)cc1)C(=O)c2ccccc2
InChI=1S/C22H27ClN4O3/c1-27(20(28)14-26-22(30)18(25)9-5-6-12-24)19-11-10-16(23)13-17(19)21(29)15-7-3-2-4-8-15/h2-4,7-8,10-11,13,18H,5-6,9,12,14,24-25H2,1H3,(H,26,30)/t18-/m0/s1
Y Key:LTKOVYBBGBGKTA-SFHVURJKSA-N
Y
N Y (what is this?) (verify)
Avizafone [1] (Pro-Diazepam ) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly.
Avizafone is metabolised by enzymes in the blood to form the active drug diazepam. It is used mainly as an antidote to poisoning with organophosphate nerve agents.[2] [3] [4]
^ GB 1517164
^ Karlsson B, Lindgren B, Millquist E, Sandberg M, Sellström A (April 1990). "On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig". The Journal of Pharmacy and Pharmacology . 42 (4): 247–51. doi:10.1111/j.2042-7158.1990.tb05401.x. PMID 1974291. S2CID 32369013.
^ Lallement G, Renault F, Baubichon D, Peoc'h M, Burckhart MF, Galonnier M, et al. (October 2000). "Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics". Archives of Toxicology . 74 (8): 480–6. doi:10.1007/s002040000146. PMID 11097386. S2CID 22292597.
^ Taysse L, Calvet JH, Buée J, Christin D, Delamanche S, Breton P (June 2003). "Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose". Toxicology . 188 (2–3): 197–209. doi:10.1016/s0300-483x(03)00086-6. PMID 12767691.
Last Update: 2024-03-23T18:11:32Z
Avizafone (Pro-Diazepam) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly. Avizafone is metabolised...
Word Count : 220
Last Update: 2024-03-08T03:06:03Z
parent compound (rilmazafone), which has no diazepine ring. Rilmazolam Avizafone Alprazolam triazolobenzophenone GL-II-73 DE Patent 2725164 Yamamoto K...
Word Count : 528
Last Update: 2024-04-11T04:52:38Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 10073
Last Update: 2024-05-13T23:06:16Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 3083
Last Update: 2024-05-26T21:23:11Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 5291
Last Update: 2024-03-18T14:50:10Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 6821
Last Update: 2024-05-20T01:29:28Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 8518
Last Update: 2024-05-24T22:06:01Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 8001
Last Update: 2024-05-28T10:31:00Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 7608
Last Update: 2024-05-18T02:46:18Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 5621
Last Update: 2024-05-25T08:29:55Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 2503
Last Update: 2024-05-19T18:14:47Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 2425
Last Update: 2024-05-25T10:45:05Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 1924
Last Update: 2023-12-20T19:27:11Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 838
Last Update: 2024-05-25T10:58:02Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 16667
Last Update: 2024-05-25T01:51:14Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 8228
Last Update: 2024-05-25T11:08:14Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 4003
Last Update: 2024-05-25T01:56:24Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 4938
Last Update: 2024-05-27T00:54:43Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 5125
Last Update: 2024-05-13T04:35:47Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 1575
Last Update: 2024-05-26T23:34:08Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 5515
Last Update: 2024-05-28T05:29:12Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 11704
Last Update: 2024-05-25T01:52:36Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 7417
Last Update: 2024-04-05T08:14:20Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 2743
Last Update: 2024-05-25T11:01:36Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 7039
Last Update: 2024-05-25T01:19:31Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 3723
Last Update: 2024-05-25T01:58:22Z
Benzodiazepines 2-Oxoquazepam 3-Hydroxyphenazepam Adinazolam Alprazolam Arfendazam Avizafone Bentazepam Bretazenil Bromazepam Bromazolam Brotizolam Camazepam Carburazepam...
Word Count : 6012