Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene.[3][4][5][6] Two transcript variants encoding two different isoforms have been found for this gene.[6]
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ApolipoproteinL1 is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different isoforms have been found for...
Inaxaplin (VX-147) is a small-molecule apolipoproteinL1 inhibitor developed by Vertex Pharmaceuticals for APOL1-mediated kidney disease. In preliminary...
therapy drug Trikafta, APOL1-mediated kidney disease experimental apolipoproteinL1 inhibitor, VX-147, and pain programs into the clinic. The company...
Organization. Normally, humans have natural trypanolytic protein called apolipoproteinL1 (APOL1) that kills different species of trypanosomes during infection...
are the type of hemoglobin inheritance, myosin heavy chain 9, and apolipoproteinL1 genes. In those with the HbSS or HbSβ0 (no normal hemoglobin), they...
in 7300 BP. Throughout Africa, various genetic adaptations (e.g., apolipoproteinL1 (APOL1): G1 and G2 haplotype resistance to trypanosomiasis and increased...
Freedman, B. I.; Divers, J. (2017). "Effect of Replacing Race With ApolipoproteinL1 Genotype in Calculation of Kidney Donor Risk Index". American Journal...
generated the first animal model and showed that genetic variants in ApolipoproteinL1 (APOL1) observed only in African American Americans cause kidney disease...
Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene. This gene is a member of the apolipoprotein L gene family and protein in this...
example, sortilin has been identified as an important receptor for brain apolipoprotein E (APOE) metabolism, which is implicated in the underlying mechanisms...
Aβ concentration in the brain. However, in patients with increased apolipoprotein (APOE) e4 carriers, Bapineuzumab treatment is also accompanied by vasogenic...
(January 16, 2001). "LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes". Proceedings of the National Academy...
secreted isoform is by far the dominant species transcribed. Secreted CLU (apolipoprotein J) is an approximately 60 kDa disulfide-linked heterodimeric glycoprotein...
ATP Binding Cassette transporter isoforms A1, G1, G5, and G8 ApoE – Apolipoprotein E CETP – CholEsterylester Transfer Protein FAS – Fatty Acid Synthase...
genetic variations association with AMD include complement factors, apolipoprotein E, fibroblast growth factor 2, DNA excision repair protein, and age-related...
A decrease in free fatty acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL-C turnover and reducing...
Kardassis D (March 2001). "Transcriptional regulation of the human apolipoprotein genes". Front. Biosci. 6: D456–504. doi:10.2741/Zannis. PMID 11229886...
transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression". The Journal of Biological Chemistry. 274 (13): 9013–21...
et al. (2002). "A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing". J. Biol. Chem. 276 (49): 46445–52. doi:10.1074/jbc...
et al. (Jan 2001). "LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes". Proceedings of the National Academy...
Herscovitz H (August 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident...
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