negative regulation of protein homooligomerization
response to misfolded protein
chaperone-mediated protein complex assembly
positive regulation of tau-protein kinase activity
lipid metabolism
immune system process
negative regulation of amyloid-beta formation
positive regulation of nitric oxide biosynthetic process
complement activation
response to virus
protein stabilization
platelet degranulation
positive regulation of neuron death
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of neurofibrillary tangle assembly
microglial cell activation
protein import
intrinsic apoptotic signaling pathway
positive regulation of amyloid-beta formation
regulation of neuronal signal transduction
microglial cell proliferation
positive regulation of NF-kappaB transcription factor activity
positive regulation of ubiquitin-dependent protein catabolic process
cell morphogenesis
regulation of neuron death
complement activation, classical pathway
positive regulation of tumor necrosis factor production
positive regulation of apoptotic process
regulation of amyloid-beta clearance
innate immune response
positive regulation of intrinsic apoptotic signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
release of cytochrome c from mitochondria
reverse cholesterol transport
chaperone-mediated protein folding
antimicrobial humoral response
cell death
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1191
12759
Ensembl
ENSG00000120885
ENSMUSG00000022037
UniProt
P10909
Q06890
RefSeq (mRNA)
NM_001831
NM_013492
RefSeq (protein)
NP_001822
NP_038520
Location (UCSC)
Chr 8: 27.6 – 27.61 Mb
Chr 14: 66.21 – 66.22 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
In humans, clusterin (CLU) is encoded by the CLU gene on chromosome 8.[5] CLU is an extracellular molecular chaperone which binds to misfolded proteins in body fluids to neutralise their toxicity and mediate their cellular uptake by receptor-mediated endocytosis. Once internalised by cells, complexes between CLU and misfolded proteins are trafficked to lysosomes where they are degraded. [6] CLU is involved in many diseases including neurodegenerative diseases, cancers, inflammatory diseases, and aging.[7][8][9]
^ abcGRCh38: Ensembl release 89: ENSG00000120885 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022037 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: clusterin".
^Wyatt, Amy R.; Yerbury, Justin J.; Ecroyd, Heath; Wilson, Mark R. (2013). "Extracellular chaperones and proteostasis". Annual Review of Biochemistry. 82: 295–322. doi:10.1146/annurev-biochem-072711-163904. ISSN 1545-4509. PMID 23350744.
^Koltai T (2014). "Clusterin: a key player in cancer chemoresistance and its inhibition". OncoTargets and Therapy. 7: 447–56. doi:10.2147/OTT.S58622. PMC 3964162. PMID 24672247.
^Sansanwal P, Li L, Sarwal MM (Mar 2015). "Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis". Journal of the American Society of Nephrology. 26 (3): 612–25. doi:10.1681/ASN.2013060577. PMC 4341467. PMID 25071085.
^Lin CC, Tsai P, Sun HY, Hsu MC, Lee JC, Wu IC, Tsao CW, Chang TT, Young KC (Nov 2014). "Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production". Journal of Hepatology. 61 (5): 984–93. doi:10.1016/j.jhep.2014.06.026. PMID 24996046.
In humans, clusterin (CLU) is encoded by the CLU gene on chromosome 8. CLU is an extracellular molecular chaperone which binds to misfolded proteins in...
Liberation – University Czech Lacrosse Union CLU (gene), the gene for clusterin CLU (programming language) Clu (Tron), fictional character from the Tron...
treatment of cancer. It is an antisense oligonucleotide (ASO) targeting clusterin expression. In metastatic prostate cancer, custirsen showed no benefit...
can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker...
the complement cascade, the formation of the membrane attack complex. Clusterin, a soluble molecule with functions similar to CD59, forms a complex with...
genes. Antiapoptotic proteins, such as clusterin and survivin, are often expressed in cancer cells. Clusterin and survivin-targeting siRNAs were used...
complexes do not bind to cell membranes and are ultimately scavenged by clusterin and vitronectin, two regulators of complement. The membrane attack complex...
human plasma proteins as major clients for the extracellular chaperone clusterin". The Journal of Biological Chemistry. 285 (6): 3532–3539. doi:10.1074/jbc...
Clusterin associated protein 1, also known as CLUAP1, is a human gene. GRCh38: Ensembl release 89: ENSG00000103351 – Ensembl, May 2017 GRCm38: Ensembl...
supported by urinary biomarkers, such as kidney injury molecule-1 (KIM-1), clusterin, and osteopontin (OPN), and in humans, insulin-like growth factor binding...
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