APOL2 information

APOL2
Identifiers
Aliases	APOL2, APOL-II, APOL3, apolipoprotein L2
External IDs	OMIM: 607252; MGI: 2444921; HomoloGene: 12785; GeneCards: APOL2; OMA:APOL2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,239,954 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	77,641,203 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; anterior pituitary; ; internal globus pallidus; ; blood; ; cerebellar hemisphere; ; monocyte; ; tibial nerve; ; smooth muscle tissue; ; upper lobe of left lung; ; lymph node;
	Top expressed in
	bone marrow; ; facial motor nucleus; ; substantia nigra; ; spleen; ; superior frontal gyrus; ; anterior horn of spinal cord; ; body of femur; ; cerebellar cortex; ; Region I of hippocampus proper; ; medial vestibular nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; lipid binding; high-density lipoprotein particle binding;
Cellular component	cytoplasm; extracellular region; endoplasmic reticulum membrane; membrane;
Biological process	multicellular organism development; lipoprotein metabolic process; lipid transport; cholesterol metabolic process; acute-phase response; maternal process involved in female pregnancy; lipid metabolism; transport;
	Sources:Amigo / QuickGO
Orthologs
	23780
	239552
	ENSG00000128335
	ENSMUSG00000056656
	Q9BQE5
	n/a
	NM_030882; NM_145637
	NM_001081970; NM_001357895; NM_001357896
	NP_112092; NP_663612
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.^[5]^[6]^[7]

This gene is a member of the apolipoprotein L gene family and protein in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is mainly found in the cytosol, nucleoplasm and additionally, it is also seen in the Nuclear bodies.^[8] The involvement of this gene may affect in the movement of lipids and binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
^ ^a ^b "Entrez Gene: APOL2 apolipoprotein L, 2".
^ "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056656 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[pmid11374903-6] Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.

[entrez-7] "Entrez Gene: APOL2 apolipoprotein L, 2".

[Protein_Location-8] "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2".