Liver X receptor alpha information

NR1H3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UHL, 3IPQ, 3IPS, 3IPU, 5AVI, 5AVL, 5HJS
Identifiers
Aliases	NR1H3, LXR-a, LXRA, RLD-1, Liver X receptor alpha, nuclear receptor subfamily 1 group H member 3
External IDs	OMIM: 602423; MGI: 1352462; HomoloGene: 21165; GeneCards: NR1H3; OMA:NR1H3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,269,032 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,033,179 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; spleen; ; tibial nerve; ; subcutaneous adipose tissue; ; canal of the cervix; ; gallbladder; ; lymph node; ; right lobe of thyroid gland; ; right adrenal cortex;
	Top expressed in
	right kidney; ; left lobe of liver; ; Ileal epithelium; ; muscle of thigh; ; lactiferous gland; ; proximal tubule; ; brown adipose tissue; ; white adipose tissue; ; subcutaneous adipose tissue; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; zinc ion binding; nuclear receptor activity; sterol response element binding; steroid hormone receptor activity; DNA binding; sequence-specific DNA binding; metal ion binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator activity; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	receptor complex; nucleoplasm; RNA polymerase II transcription regulator complex; nucleus; cytoplasm;
Biological process	positive regulation of toll-like receptor 4 signaling pathway; sterol homeostasis; negative regulation of pancreatic juice secretion; negative regulation of inflammatory response; cellular response to lipopolysaccharide; negative regulation of lipid transport; positive regulation of lipoprotein lipase activity; lipid homeostasis; triglyceride homeostasis; negative regulation of macrophage activation; negative regulation of macrophage derived foam cell differentiation; positive regulation of cholesterol transport; negative regulation of cholesterol storage; regulation of transcription, DNA-templated; positive regulation of triglyceride biosynthetic process; positive regulation of cholesterol efflux; positive regulation of protein metabolic process; negative regulation of interferon-gamma-mediated signaling pathway; regulation of circadian rhythm; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; response to progesterone; steroid hormone mediated signaling pathway; apoptotic cell clearance; positive regulation of fatty acid biosynthetic process; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; negative regulation of secretion of lysosomal enzymes; negative regulation of pinocytosis; positive regulation of transcription, DNA-templated; intracellular receptor signaling pathway; cholesterol homeostasis; lipid metabolism; multicellular organism development; cell differentiation; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10062
	22259
	ENSG00000025434
	ENSMUSG00000002108
	Q13133
	Q9Z0Y9
	NM_001130101; NM_001130102; NM_001251934; NM_001251935; NM_005693
	NM_001177730; NM_013839; NM_001355279
NP_001123573; NP_001123574; NP_001238863; NP_001238864; NP_005684;
	NP_001350524; NP_005684.2
	NP_001171201; NP_038867; NP_001342208
	Wikidata
View/Edit Human	View/Edit Mouse

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000025434 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002108 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP (Apr 1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling". The Journal of Biological Chemistry. 271 (16): 9189–92. doi:10.1074/jbc.271.16.9189. PMID 8621574.
^ Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ (May 1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway". Genes & Development. 9 (9): 1033–45. doi:10.1101/gad.9.9.1033. PMID 7744246.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000025434 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002108 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8621574-5] Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP (Apr 1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling". The Journal of Biological Chemistry. 271 (16): 9189–92. doi:10.1074/jbc.271.16.9189. PMID 8621574.

[pmid7744246-6] Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ (May 1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway". Genes & Development. 9 (9): 1033–45. doi:10.1101/gad.9.9.1033. PMID 7744246.

Liver X receptor alpha information

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