hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
protein binding
catalytic activity
RNA binding
hydrolase activity
identical protein binding
Cellular component
cytoplasm
P-body
apolipoprotein B mRNA editing enzyme complex
nucleus
ribonucleoprotein complex
Biological process
negative regulation of transposition
negative regulation of viral process
immune system process
base conversion or substitution editing
negative regulation of viral genome replication
defense response to virus
DNA cytosine deamination
DNA demethylation
innate immune response
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of defense response to virus by host
cytidine deamination
cytidine to uridine editing
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
200316
n/a
Ensembl
ENSG00000128394
n/a
UniProt
Q8IUX4
n/a
RefSeq (mRNA)
NM_001006666 NM_145298
n/a
RefSeq (protein)
NP_001006667 NP_660341
n/a
Location (UCSC)
Chr 22: 39.04 – 39.06 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.[3][4][5]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000128394 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
^Holmes RK, Koning FA, Bishop KN, Malim MH (Jan 2007). "APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G". J Biol Chem. 282 (4): 2587–95. doi:10.1074/jbc.M607298200. PMID 17121840.
dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene. This gene is a member of the cytidine deaminase gene family. It is...
for protection against retroviruses such as HIV(known to be modified by APOBEC3F and APOBEC3G). Since their original functions include editing ssDNA, they...
with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging". Journal of Molecular Biology. 375 (4): 1098–1112. doi:10...
Activity Spectrum of Vif from Multiple HIV-1 Subtypes against APOBEC3G, APOBEC3F, and APOBEC3H". Journal of Virology. 86 (1): 49–59. doi:10.1128/JVI.06082-11...
PMC 1326241. PMID 16407327. Stenglein MD, Harris RS (2006). "APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism"...
"Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target...
JS, Harki DA, Amaro RE, Harris RS "The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.", Cell...
Global Information
