Katalin Susztak information

Katalin Susztak
Katalin Susztak
Born	Eger, Hungary
Nationality	Hungarian-American
Alma mater	Semmelweis University, Albert Einstein College of Medicine
Occupation	Nephrologist

Katalin Susztak (Suszták) is a Hungarian American scientist and nephrologist at the Perelman School of Medicine at the University of Pennsylvania. She is a professor of medicine and genetics, and currently the codirector of the Complications Unit at the Institute for Diabetes, Obesity and Metabolism. Her laboratory made major contributions to the current understanding of kidney disease development.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10] She is also the founder of the Transformative Research In DiabEtic NephropaThy (TRIDENT),^[11] a collaborative network of physicians and basic scientists, to find cures for diabetic kidney disease.

^ Susztak, Katalin; Raff, Amanda C.; Schiffer, Mario; Böttinger, Erwin P. (January 2006). "Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy". Diabetes. 55 (1): 225–233. doi:10.2337/diabetes.55.01.06.db05-0894. ISSN 0012-1797. PMID 16380497.
^ Niranjan, Thiruvur; Bielesz, Bernhard; Gruenwald, Antje; Ponda, Manish P.; Kopp, Jeffrey B.; Thomas, David B.; Susztak, Katalin (March 2008). "The Notch pathway in podocytes plays a role in the development of glomerular disease". Nature Medicine. 14 (3): 290–298. doi:10.1038/nm1731. ISSN 1546-170X. PMID 18311147. S2CID 29990985.
^ Ko, Yi-An; Mohtat, Davoud; Suzuki, Masako; Park, Ae Seo Deok; Izquierdo, Maria Concepcion; Han, Sang Youb; Kang, Hyun Mi; Si, Han; Hostetter, Thomas; Pullman, James M.; Fazzari, Melissa (2013). "Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development". Genome Biology. 14 (10): R108. doi:10.1186/gb-2013-14-10-r108. ISSN 1474-760X. PMC 4053753. PMID 24098934.
^ Kang, Hyun Mi; Ahn, Seon Ho; Choi, Peter; Ko, Yi-An; Han, Seung Hyeok; Chinga, Frank; Park, Ae Seo Deok; Tao, Jianling; Sharma, Kumar; Pullman, James; Bottinger, Erwin P. (January 2015). "Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development". Nature Medicine. 21 (1): 37–46. doi:10.1038/nm.3762. ISSN 1546-170X. PMC 4444078. PMID 25419705.
^ Beckerman, Pazit; Bi-Karchin, Jing; Park, Ae Seo Deok; Qiu, Chengxiang; Dummer, Patrick D.; Soomro, Irfana; Boustany-Kari, Carine M.; Pullen, Steven S.; Miner, Jeffrey H.; Hu, Chien-An A.; Rohacs, Tibor (April 2017). "Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice". Nature Medicine. 23 (4): 429–438. doi:10.1038/nm.4287. ISSN 1546-170X. PMC 5603285. PMID 28218918.
^ Park, Jihwan; Shrestha, Rojesh; Qiu, Chengxiang; Kondo, Ayano; Huang, Shizheng; Werth, Max; Li, Mingyao; Barasch, Jonathan; Suszták, Katalin (2018-05-18). "Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease". Science. 360 (6390): 758–763. doi:10.1126/science.aar2131. ISSN 1095-9203. PMC 6188645. PMID 29622724.
^ Qiu, Chengxiang; Huang, Shizheng; Park, Jihwan; Park, YoSon; Ko, Yi-An; Seasock, Matthew J.; Bryer, Joshua S.; Xu, Xiang-Xi; Song, Wen-Chao; Palmer, Matthew; Hill, Jon (November 2018). "Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease". Nature Medicine. 24 (11): 1721–1731. doi:10.1038/s41591-018-0194-4. ISSN 1546-170X. PMC 6301011. PMID 30275566.
^ Chung, Ki Wung; Dhillon, Poonam; Huang, Shizheng; Sheng, Xin; Shrestha, Rojesh; Qiu, Chengxiang; Kaufman, Brett A.; Park, Jihwan; Pei, Liming; Baur, Joseph; Palmer, Matthew (2019-10-01). "Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis". Cell Metabolism. 30 (4): 784–799.e5. doi:10.1016/j.cmet.2019.08.003. ISSN 1932-7420. PMC 7054893. PMID 31474566.
^ Dhillon, Poonam; Park, Jihwan; Hurtado Del Pozo, Carmen; Li, Lingzhi; Doke, Tomohito; Huang, Shizheng; Zhao, Juanjuan; Kang, Hyun Mi; Shrestra, Rojesh; Balzer, Michael S.; Chatterjee, Shatakshee (2021-02-02). "The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation". Cell Metabolism. 33 (2): 379–394.e8. doi:10.1016/j.cmet.2020.11.011. ISSN 1932-7420. PMC 9259369. PMID 33301705. S2CID 228100288.
^ Sheng, Xin; Qiu, Chengxiang; Liu, Hongbo; Gluck, Caroline; Hsu, Jesse Y.; He, Jiang; Hsu, Chi-Yuan; Sha, Daohang; Weir, Matthew R.; Isakova, Tamara; Raj, Dominic (2020-11-17). "Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease". Proceedings of the National Academy of Sciences of the United States of America. 117 (46): 29013–29024. Bibcode:2020PNAS..11729013S. doi:10.1073/pnas.2005905117. ISSN 1091-6490. PMC 7682409. PMID 33144501.
^ "TRIDENT - University of Pennsylvania".

[:0-1] Susztak, Katalin; Raff, Amanda C.; Schiffer, Mario; Böttinger, Erwin P. (January 2006). "Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy". Diabetes. 55 (1): 225–233. doi:10.2337/diabetes.55.01.06.db05-0894. ISSN 0012-1797. PMID 16380497.

[:1-2] Niranjan, Thiruvur; Bielesz, Bernhard; Gruenwald, Antje; Ponda, Manish P.; Kopp, Jeffrey B.; Thomas, David B.; Susztak, Katalin (March 2008). "The Notch pathway in podocytes plays a role in the development of glomerular disease". Nature Medicine. 14 (3): 290–298. doi:10.1038/nm1731. ISSN 1546-170X. PMID 18311147. S2CID 29990985.

[:2-3] Ko, Yi-An; Mohtat, Davoud; Suzuki, Masako; Park, Ae Seo Deok; Izquierdo, Maria Concepcion; Han, Sang Youb; Kang, Hyun Mi; Si, Han; Hostetter, Thomas; Pullman, James M.; Fazzari, Melissa (2013). "Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development". Genome Biology. 14 (10): R108. doi:10.1186/gb-2013-14-10-r108. ISSN 1474-760X. PMC 4053753. PMID 24098934.

[:3-4] Kang, Hyun Mi; Ahn, Seon Ho; Choi, Peter; Ko, Yi-An; Han, Seung Hyeok; Chinga, Frank; Park, Ae Seo Deok; Tao, Jianling; Sharma, Kumar; Pullman, James; Bottinger, Erwin P. (January 2015). "Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development". Nature Medicine. 21 (1): 37–46. doi:10.1038/nm.3762. ISSN 1546-170X. PMC 4444078. PMID 25419705.

[:4-5] Beckerman, Pazit; Bi-Karchin, Jing; Park, Ae Seo Deok; Qiu, Chengxiang; Dummer, Patrick D.; Soomro, Irfana; Boustany-Kari, Carine M.; Pullen, Steven S.; Miner, Jeffrey H.; Hu, Chien-An A.; Rohacs, Tibor (April 2017). "Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice". Nature Medicine. 23 (4): 429–438. doi:10.1038/nm.4287. ISSN 1546-170X. PMC 5603285. PMID 28218918.

[:5-6] Park, Jihwan; Shrestha, Rojesh; Qiu, Chengxiang; Kondo, Ayano; Huang, Shizheng; Werth, Max; Li, Mingyao; Barasch, Jonathan; Suszták, Katalin (2018-05-18). "Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease". Science. 360 (6390): 758–763. doi:10.1126/science.aar2131. ISSN 1095-9203. PMC 6188645. PMID 29622724.

[:6-7] Qiu, Chengxiang; Huang, Shizheng; Park, Jihwan; Park, YoSon; Ko, Yi-An; Seasock, Matthew J.; Bryer, Joshua S.; Xu, Xiang-Xi; Song, Wen-Chao; Palmer, Matthew; Hill, Jon (November 2018). "Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease". Nature Medicine. 24 (11): 1721–1731. doi:10.1038/s41591-018-0194-4. ISSN 1546-170X. PMC 6301011. PMID 30275566.

[:7-8] Chung, Ki Wung; Dhillon, Poonam; Huang, Shizheng; Sheng, Xin; Shrestha, Rojesh; Qiu, Chengxiang; Kaufman, Brett A.; Park, Jihwan; Pei, Liming; Baur, Joseph; Palmer, Matthew (2019-10-01). "Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis". Cell Metabolism. 30 (4): 784–799.e5. doi:10.1016/j.cmet.2019.08.003. ISSN 1932-7420. PMC 7054893. PMID 31474566.

[:8-9] Dhillon, Poonam; Park, Jihwan; Hurtado Del Pozo, Carmen; Li, Lingzhi; Doke, Tomohito; Huang, Shizheng; Zhao, Juanjuan; Kang, Hyun Mi; Shrestra, Rojesh; Balzer, Michael S.; Chatterjee, Shatakshee (2021-02-02). "The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation". Cell Metabolism. 33 (2): 379–394.e8. doi:10.1016/j.cmet.2020.11.011. ISSN 1932-7420. PMC 9259369. PMID 33301705. S2CID 228100288.

[10] Sheng, Xin; Qiu, Chengxiang; Liu, Hongbo; Gluck, Caroline; Hsu, Jesse Y.; He, Jiang; Hsu, Chi-Yuan; Sha, Daohang; Weir, Matthew R.; Isakova, Tamara; Raj, Dominic (2020-11-17). "Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease". Proceedings of the National Academy of Sciences of the United States of America. 117 (46): 29013–29024. Bibcode:2020PNAS..11729013S. doi:10.1073/pnas.2005905117. ISSN 1091-6490. PMC 7682409. PMID 33144501.

[11] "TRIDENT - University of Pennsylvania".

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