Mothers against decapentaplegic homolog 2 information

SMAD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DEV, 1KHX, 1U7V, 2LB3
Identifiers
Aliases	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD8
External IDs	OMIM: 601366 MGI: 108051 HomoloGene: 21197 GeneCards: SMAD2
Gene location (Human)
Chr.	Chromosome 18 (human)
End	47,931,146 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	76,444,034 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sperm; ; secondary oocyte; ; germinal epithelium; ; monocyte; ; islet of Langerhans; ; amniotic fluid; ; hair follicle; ; endothelial cell; ; sural nerve;
	Top expressed in
	saccule; ; otic placode; ; secondary oocyte; ; endocardial cushion; ; trigeminal ganglion; ; ganglionic eminence; ; nerve fiber layer; ; sciatic nerve; ; atrioventricular valve; ; hand;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; I-SMAD binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding; co-SMAD binding; transcription factor binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; protein homodimerization activity; chromatin binding; protein binding; double-stranded DNA binding; SMAD binding; DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; primary miRNA binding; disordered domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; tau protein binding;
Cellular component	cytoplasm; cytosol; nucleus; heteromeric SMAD protein complex; SMAD protein complex; transcription regulator complex; intracellular anatomical structure; nucleoplasm; activin responsive factor complex; protein-containing complex;
Biological process	pattern specification process; ureteric bud development; endoderm development; response to cholesterol; organ growth; embryonic pattern specification; zygotic specification of dorsal/ventral axis; post-embryonic development; protein phosphorylation; pericardium development; regulation of binding; transforming growth factor beta receptor signaling pathway; negative regulation of cell population proliferation; cell fate commitment; common-partner SMAD protein phosphorylation; regulation of transcription, DNA-templated; SMAD protein signal transduction; lung development; signal transduction involved in regulation of gene expression; insulin secretion; in utero embryonic development; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of gene expression; nodal signaling pathway; positive regulation of transcription, DNA-templated; heart development; pancreas development; endoderm formation; activin receptor signaling pathway; SMAD protein complex assembly; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; embryonic foregut morphogenesis; negative regulation of transcription by RNA polymerase II; response to glucose; positive regulation of epithelial to mesenchymal transition; developmental growth; gastrulation; primary miRNA processing; positive regulation of BMP signaling pathway; embryonic cranial skeleton morphogenesis; negative regulation of transcription, DNA-templated; paraxial mesoderm morphogenesis; intracellular signal transduction; somatic stem cell population maintenance; mesoderm formation; regulation of transforming growth factor beta receptor signaling pathway; positive regulation of gene expression; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; transcription by RNA polymerase II; protein deubiquitination; wound healing; adrenal gland development; secondary palate development;
	Sources:Amigo / QuickGO
Orthologs
	4087
	17126
	ENSG00000175387
	ENSMUSG00000024563
	Q15796
	Q62432
	NM_001003652; NM_001135937; NM_005901
	NM_001252481; NM_010754; NM_001311070
	NP_001003652; NP_001129409; NP_005892
	NP_001239410; NP_001297999; NP_034884
	Wikidata
View/Edit Human	View/Edit Mouse

Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene.^[5]^[6] MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175387 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024563 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L (August 1996). "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma". Cell. 86 (4): 543–52. doi:10.1016/S0092-8674(00)80128-2. PMID 8752209. S2CID 531842.
^ Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. S2CID 10124489.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175387 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024563 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8752209-5] Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L (August 1996). "MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma". Cell. 86 (4): 543–52. doi:10.1016/S0092-8674(00)80128-2. PMID 8752209. S2CID 531842.

[pmid8673135-6] Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. S2CID 10124489.

Mothers against decapentaplegic homolog 2 information

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