regulation of blood coagulation, intrinsic pathway
response to nutrient
negative regulation of endopeptidase activity
lactation
acute inflammatory response to antigenic stimulus
regulation of blood coagulation
post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
462
11905
Ensembl
ENSG00000117601
ENSMUSG00000026715
UniProt
P01008
P32261
RefSeq (mRNA)
NM_000488 NM_001365052
NM_080844 NM_001379302
RefSeq (protein)
NP_000479 NP_001351981
NP_543120 NP_001366231
Location (UCSC)
Chr 1: 173.9 – 173.92 Mb
Chr 1: 160.81 – 160.83 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites. A single glycosylation site remains consistently un-occupied in the minor form of antithrombin, β-antithrombin.[5] Its activity is increased manyfold by the anticoagulant drug heparin, which enhances the binding of antithrombin to factor IIa (thrombin) and factor Xa.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000117601 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026715 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bjork I, Olson, JE (1997). Antithrombin, A bloody important serpin (in Chemistry and Biology of Serpins). Plenum Press. pp. 17–33. ISBN 978-0-306-45698-5.
^Finley A, Greenberg C (2013-06-01). "Review article: heparin sensitivity and resistance: management during cardiopulmonary bypass". Anesthesia and Analgesia. 116 (6): 1210–1222. doi:10.1213/ANE.0b013e31827e4e62. ISSN 1526-7598. PMID 23408671. S2CID 22500786.
Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver...
Antithrombin III deficiency (abbreviated ATIII deficiency) is a deficiency of antithrombin III. This deficiency may be inherited or acquired. It is a rare...
approves Antithrombin as an anticoagulant for preventing clots before, during, or after surgery or birthing in patients with hereditary antithrombin deficiency...
direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa. Fondaparinux...
levels of FVIII, also may lead to a thrombotic tendency.[citation needed] Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases:...
and rechecking laboratory values. Use in antithrombin III deficiency: FFP can be used as a source of antithrombin III in patients who are deficient of this...
ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company rEVO Biologics (formerly known as GTC Biotherapeutics)...
the coagulation cascade. In human adults, the normal blood level of antithrombin activity has been measured to be around 1.1 units/mL. Newborn levels...
cascade. Heparin works by binding to and activating the enzyme inhibitor antithrombin III, an enzyme that acts by inactivating thrombin and factor Xa. In contrast...
transaccional (Spanish for "transactional analysis"), a psychological method Antithrombin, a small protein molecule Ataxia–telangiectasia, an immunodeficiency...
glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It...
reported in the late 1800s, but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated, with the subsequent recognition...
principal inhibitor of thrombin in normal blood circulation is antithrombin. Similar to antithrombin, the anticoagulant activity of hirudin is based on its ability...
the Antithrombin molecules in neonates and children is larger than in adults. Antithrombin: the levels of antithrombin increase with age. Antithrombin levels...
excessive protease-triggered activation of its own complement system), antithrombin (which protects the body from excessive coagulation), plasminogen activator...
VTE rates. Genetic factors include non-O blood type, deficiencies of antithrombin, protein C, and protein S and the mutations of factor V Leiden and prothrombin...
first major form of thrombophilia to be identified by medical science, antithrombin deficiency, was identified in 1965, while the most common abnormalities...
bleeding and neurological changes. Enoxaparin binds to and potentiates antithrombin (a circulating anticoagulant) to form a complex that irreversibly inactivates...
lead to mutations through intrastrand and interstrand switching. The antithrombin III gene's coding region is an example of an imperfect inverted repeat...
"Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational...
reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial...
clotting, including heparan sulfate which acts as a cofactor for activating antithrombin, a protein that inactivates several factors in the coagulation cascade...
particularly those caused by a decrease in blood antithrombin III levels due to leakage. Antithrombin III counteracts the action of thrombin. Thrombosis...
Global Information
