Soluble protein complex in blood plasma and involved in clot formation
Fibrinogen alpha/beta chain family
crystal structure of native chicken fibrinogen with two different bound ligands
Identifiers
Symbol
Fib_alpha
Pfam
PF08702
InterPro
IPR012290
SCOP2
1m1j / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Fibrinogen alpha C domain
Identifiers
Symbol
Fibrinogen_aC
Pfam
PF12160
InterPro
IPR021996
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Identifiers
Symbol
Fibrinogen_C
Pfam
PF00147
Pfam clan
CL0422
InterPro
IPR002181
PROSITE
PDOC00445
SCOP2
1fza / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver,[1] that circulates in the blood of all vertebrates.[2] During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting.[1] Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing.[3]
Reduced and/or dysfunctional fibrinogens occur in various congenital and acquired human fibrinogen-related disorders. These disorders represent a group of rare conditions in which individuals may present with severe episodes of pathological bleeding and thrombosis; these conditions are treated by supplementing blood fibrinogen levels and inhibiting blood clotting, respectively.[4][5] These disorders may also be the cause of certain liver and kidney diseases.[1]
Fibrinogen is a "positive" acute-phase protein, i.e. its blood levels rise in response to systemic inflammation, tissue injury, and certain other events. It is also elevated in various cancers. Elevated levels of fibrinogen in inflammation as well as cancer and other conditions have been suggested to be the cause of thrombosis and vascular injury that accompanies these conditions.[6][7]
^ abcde Moerloose P, Casini A, Neerman-Arbez M (September 2013). "Congenital fibrinogen disorders: an update". Seminars in Thrombosis and Hemostasis. 39 (6): 585–595. doi:10.1055/s-0033-1349222. PMID 23852822.
^Jiang Y, Doolittle RF (June 2003). "The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes". Proceedings of the National Academy of Sciences of the United States of America. 100 (13): 7527–7532. Bibcode:2003PNAS..100.7527J. doi:10.1073/pnas.0932632100. PMC 164620. PMID 12808152.
^Mosesson MW (August 2005). "Fibrinogen and fibrin structure and functions". Journal of Thrombosis and Haemostasis. 3 (8): 1894–1904. doi:10.1111/j.1538-7836.2005.01365.x. PMID 16102057. S2CID 22077267.
^Casini A, de Moerloose P, Neerman-Arbez M (June 2016). "Clinical Features and Management of Congenital Fibrinogen Deficiencies". Seminars in Thrombosis and Hemostasis. 42 (4): 366–374. doi:10.1055/s-0036-1571339. PMID 27019462. S2CID 12038872.
^Undas A (September 2011). "Acquired dysfibrinogenemia in atherosclerotic vascular disease". Polskie Archiwum Medycyny Wewnetrznej. 121 (9): 310–319. PMID 21952526.
^Davalos D, Akassoglou K (January 2012). "Fibrinogen as a key regulator of inflammation in disease". Seminars in Immunopathology. 34 (1): 43–62. doi:10.1007/s00281-011-0290-8. PMID 22037947. S2CID 14997530.
^Repetto O, De Re V (September 2017). "Coagulation and fibrinolysis in gastric cancer". Annals of the New York Academy of Sciences. 1404 (1): 27–48. Bibcode:2017NYASA1404...27R. doi:10.1111/nyas.13454. PMID 28833193. S2CID 10878584.
Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and...
Fibrinogen deficiency, also known as factor I deficiency, is a rare inherited bleeding disorder related to fibrinogen function in the coagulation cascade...
increasing its affinity to bind fibrinogen. The activated platelets change shape from spherical to stellate, and the fibrinogen cross-links with glycoprotein...
Fibrinogen disorders are a set of hereditary or acquired abnormalities in the quantity and/or quality of circulating fibrinogens. The disorders may lead...
The levels of these FDPs rise after any thrombotic event. Fibrin and fibrinogen degradation product (FDP) testing is commonly used to diagnose disseminated...
Fibrinogen gamma chain, also known as fibrinogen gamma gene (FGG), is a human gene found on chromosome 3. The protein encoded by this gene is the gamma...
clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together with...
Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation. The protein...
Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha component of fibrinogen, a...
and lipids assisting in immune function. Fibrinogen comprises 7% of blood proteins; conversion of fibrinogen to insoluble fibrin is essential for blood...
change of ecological niche. Sequence analysis of intron 7 of the nuclear β-fibrinogen gene, on the other hand, indicates that it may yet be distinct enough...
hereditary fibrinogen disorder cause by mutations in one or more of the genes that encode a factor critical for blood clotting, fibrinogen. These mutations...
dysfibrinogenemias consist of three types of fibrinogen disorders in which a critical blood clotting factor, fibrinogen, circulates at normal levels but is dysfunctional...
repair surgeries or wound healing. It contains separately packaged human fibrinogen and human thrombin. This glue is used as a supportive treatment in surgery...
typically based on blood tests. Findings may include low platelets, low fibrinogen, high INR, or high D-dimer. Treatment is mainly directed towards the underlying...
converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions. After the description of fibrinogen and...
enzyme that promotes the degradation of fibrin in clots but not free fibrinogen. This drug is made by transgenic bacteria and converts plasminogen into...
A fibrinogen uptake test is a test that was formerly used to detect deep vein thrombosis. Radioactive labeled fibrinogen is given which is incorporated...
by the aggregation of red blood cells: blood plasma proteins, mainly fibrinogen, promote the formation of red cell clusters called rouleaux or larger...
first line, followed by factor concentrates. Hypofibrinogenaemia (low fibrinogen levels), as can occur with massive transfusions Afibrinogenemia Bleeding...
cleavage of fibrinogen. Some of the forms have hemostatic efficacy as main effect, where the other forms have degradation of fibrinogen as main effect...
Hementin is an anticoagulant protease (fibrinogen lytic enzyme) from the salivary glands of the giant Amazon leech (Haementeria ghilianii). Hementin is...
Blood plasma Prothrombin complex concentrate, factor XIII, and fibrinogenFibrinogen with tranexamic acid The use of tranexamic acid is the only option...
plasma to clot is prolonged, a quantitative (fibrinogen deficiency) or qualitative (dysfunctional fibrinogen) defect is present. In blood samples containing...
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