Allylglycine information

Allylglycine
Names
	Preferred IUPAC name 2-Aminopent-4-enoic acid
Identifiers
CAS Number	7685-44-1 ;
3D model (JSmol)	Interactive image; Interactive image;
ChemSpider	13425 ;
ECHA InfoCard	100.028.809
PubChem CID	14044;
CompTox Dashboard (EPA)	DTXSID701313217 ;
	InChI InChI=1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8) Key: WNNNWFKQCKFSDK-UHFFFAOYSA-N ; InChI=1/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8) Key: WNNNWFKQCKFSDK-UHFFFAOYAL;
	SMILES C=CCC(C(=O)O)N; O=C(O)C(N)CC=C;
Properties
Chemical formula	C5H9NO2
Molar mass	115.13 g/mol
Appearance	white crystalline powder
Density	1.098 g/mL
Melting point	265 °C (509 °F; 538 K)
Boiling point	231 °C (448 °F; 504 K)
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Convulsant
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	147-195 mg/kg (mice, intraperitoneal)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Allylglycine is a glycine derivative. It is an inhibitor of glutamate decarboxylase.^[2] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.^[3] Allylglycine is known to induce seizures in animals studies, presumably due to this GDC-inhibiting activity.^[4]

^ Piepho, R. W; Friedman, A. H (1977). "Chronopharmacology of Strychnine and Allylglycine in the Mouse". Clinical and Experimental Pharmacology and Physiology. 4 (3): 263–6. doi:10.1111/j.1440-1681.1977.tb02623.x. PMID 891041. S2CID 25088608.
^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383. S2CID 32655173.
^ Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMC 3065212. PMID 18308797.
^ Thomas J, Yang YC (June 1991). "Allylglycine induced seizures in male and female rats". Physiol. Behav. 49 (6): 1181–3. doi:10.1016/0031-9384(91)90348-R. PMID 1654571. S2CID 10506822.

[1] Piepho, R. W; Friedman, A. H (1977). "Chronopharmacology of Strychnine and Allylglycine in the Mouse". Clinical and Experimental Pharmacology and Physiology. 4 (3): 263–6. doi:10.1111/j.1440-1681.1977.tb02623.x. PMID 891041. S2CID 25088608.

[pmid3205383-2] Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383. S2CID 32655173.

[pmid18308797-3] Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMC 3065212. PMID 18308797.

[pmid1654571-4] Thomas J, Yang YC (June 1991). "Allylglycine induced seizures in male and female rats". Physiol. Behav. 49 (6): 1181–3. doi:10.1016/0031-9384(91)90348-R. PMID 1654571. S2CID 10506822.

Allylglycine information

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Allylglycine

Hydrochloride

Glycine methyl ester hydrochloride

Ibotenic acid

Theanine

Furosemide

Alanine transaminase

Glutamate decarboxylase

Valproate

Glutamic acid

Aspartate transaminase

GABA reuptake inhibitor

Butyric acid

C5H9NO2

GABA

Chloroquine

Glossary of chemical formulae

Vigabatrin

Guanosine triphosphate

Glutamine synthetase

Phenelzine

Muscimol

Epigallocatechin gallate

Aspartic acid

Isoniazid

Trypan blue

Riluzole