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Riluzole information


Riluzole
Clinical data
Trade namesRilutek, Tiglutik, Exservan, others
AHFS/Drugs.comMonograph
MedlinePlusa696013
Pregnancy
category
  • AU: B3
Routes of
administration		By mouth
ATC code
  • N07XX02 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
  • EU: Rx Only
Pharmacokinetic data
Bioavailability60±18%[1]
Protein binding97%[1]
MetabolismHepatic (CYP1A2)[1]
Elimination half-life9–15 hours[1]
ExcretionUrine (90%)[1]
Identifiers
IUPAC name
  • 6-(trifluoromethoxy)benzothiazol-2-amine
CAS Number
  • 1744-22-5 checkY
PubChem CID
  • 5070
IUPHAR/BPS
  • 2326
DrugBank
  • DB00740 checkY
ChemSpider
  • 4892 checkY
UNII
  • 7LJ087RS6F
KEGG
  • D00775 checkY
ChEMBL
  • ChEMBL744 checkY
CompTox Dashboard (EPA)
  • DTXSID3045192 Edit this at Wikidata
ECHA InfoCard100.124.754 Edit this at Wikidata
Chemical and physical data
FormulaC8H5F3N2OS
Molar mass234.20 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • FC(F)(F)Oc1ccc2nc(sc2c1)N
InChI
  • InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) checkY
  • Key:FTALBRSUTCGOEG-UHFFFAOYSA-N checkY
  (verify)

Riluzole is a medication used to treat amyotrophic lateral sclerosis and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months.[2] Riluzole is available in tablet and liquid form.

  1. ^ a b c d e "PRODUCT INFORMATION RILUTEK® (riluzole) Tablets" (PDF). TGA eBusiness Services. sanofi-aventis australia pty ltd. January 6, 2009. Retrieved February 18, 2014.
  2. ^ Miller RG, Mitchell JD, Moore DH (March 2012). "Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)". The Cochrane Database of Systematic Reviews. 2012 (3): CD001447. doi:10.1002/14651858.CD001447.pub3. PMC 7055506. PMID 22419278.

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Promethazine

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Diphenhydramine

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