Vigabatrin, sold under the brand names Sabril and Vigpoder, is a medication used in the management and treatment of infantile spasms and refractory complex partial seizures.
It works by inhibiting the breakdown of γ-aminobutyric acid (GABA). It is also known as γ-vinyl-GABA, and is a structural analogue of GABA, but does not bind to GABA receptors.[2]
Vigabatrin is generally used only in cases of treatment-resistant epilepsy due to the risk of permanent vision loss.[3] Although estimates of visual field loss vary substantially, risk appears to be lower among infants with treatment duration less than 12 months and the risk of clinically meaningful vision loss is very low among children treated for infantile spasms.[4][5]
^Anvisa (March 31, 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published April 4, 2023). Archived from the original on August 3, 2023. Retrieved August 16, 2023.
^Long PW (2003). "Vigabatrin". Drug Monograph. Internet Mental Health. Archived from the original on April 23, 2006.
^"Sabril (vigabatrin) Tablets for Oral Use, Powder for Oral Solution. Full Prescribing Information" (PDF). Lundbeck.
^Hussain, S. A.; Schmid, E.; Peters, J. M.; Goyal, M.; Bebin, E. M.; Northrup, H.; Sahin, M.; Krueger, D. A.; Wu, J. Y.; Tuberous Sclerosis Complex Autism Center of Excellence Network; Williams, Marian E.; Hanson, Ellen; Bing, Nicole; Kent, Bridget; o'Kelley, Sarah; Filip-Dhima, Rajna; Dies, Kira; Bruns, Stephanie; Scherrer, Benoit; Cutter, Gary; Murray, Donna S.; Roberds, Steven L. (2018). "High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex". Epilepsy Research. 148: 1–7. doi:10.1016/j.eplepsyres.2018.09.016. PMC 6347124. PMID 30296632.
^Schwarz, M. D.; Li, M.; Tsao, J.; Zhou, R.; Wu, Y. W.; Sankar, R.; Wu, J. Y.; Hussain, S. A. (2016). "A lack of clinically apparent vision loss among patients treated with vigabatrin with infantile spasms: The UCLA experience". Epilepsy & Behavior : E&B. 57 (Pt A): 29–33. doi:10.1016/j.yebeh.2016.01.012. PMID 26921595.
Vigabatrin, sold under the brand names Sabril and Vigpoder, is a medication used in the management and treatment of infantile spasms and refractory complex...
increased neuronal GABA concentrations. Examples include valproic acid, vigabatrin, phenylethylidenehydrazine (and drugs that metabolize to it, such as phenelzine)...
valproate, and divalproex sodium (1967). Vigabatrin (1989). Progabide (1987). Tiagabine (1996). Vigabatrin and progabide are also analogs of GABA. Topiramate...
other adjunctive therapies. Use is restricted due to hepatotoxicity. Vigabatrin — used only in extreme treatment-resistant epilepsy due to the risk of...
Some specific anticonvulsant drugs such as phenytoin, carbamazepine, and vigabatrin have been identified to raise the chances of experiencing absence seizures...
one that reduces the levels of GHB via inhibition of GABA transaminase. Vigabatrin is an irreversible inhibitor of GABA transaminases which leads to decreased...
levetiracetam, topiramate, gabapentin, oxcarbazepine, lamotrigine, and vigabatrin) via breastmilk was not associated with negative neurodevelopment (such...
reference the compound is called a 'suicide inactivator' (not inhibitor). Vigabatrin, an anticonvulsant, is a suicide inhibitor of GABA-T. Suicide inhibitors...
of epilepsy in TSC patients include mTOR inhibitors, cannabidiol and vigabatrin. Epilepsy surgery is often pursued. Sturge-Weber syndrome is caused by...
in the preparation of several medicinally useful compounds including vigabatrin, phenylbutazone, nalidixic acid, and rebamipide. Several pesticides are...
(Prednisolone), for multiple sclerosis. Rilutek (Riluzole), for ALS. Sabril (Vigabatrin), for epilepsy, marketed by Lundbeck. – Oncology Anzemet (Dolasetron)...
(often with mood changes in addition), and some anticonvulsants such as vigabatrin. The first brain image of an individual with psychosis was completed as...
(PIGO). anticonvulsants (such as phenytoin, phenobarbital, lamotrigine, vigabatrin, ethosuximide, topiramate and primidone NOT common for valproate) calcium...
enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin". The Journal of Biological Chemistry. 279 (1): 363–373. doi:10.1074/jbc...
channels antiepileptic drugs such as valproate, lamotrigine, tiagabine, vigabatrin, carbamazepine and oxcarbazepine, and topiramate antipsychotic drugs such...
specificity has prompted further designs of ALR inhibitors. Gabaculine and Vigabatrin inhibit GABA aminotransferase Canaline and 5-fluoromethylornithine inhibit...
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