Structure of the protein core of aggrecan or chondroitin sulfate proteoglycan 1
Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage, and also play key roles in neural development and glial scar formation. They are known to be involved in certain cell processes, such as cell adhesion, cell growth, receptor binding, cell migration, and interaction with other extracellular matrix constituents.[1] They are also known to interact with laminin, fibronectin, tenascin, and collagen.[1] CSPGs are generally secreted from cells.
Importantly, CSPGs are known to inhibit axon regeneration after spinal cord injury. CSPGs contribute to glial scar formation post injury, acting as a barrier against new axons growing into the injury site.[2] CSPGs play a crucial role in explaining why the spinal cord doesn't self-regenerate after an injury.
^ abRhodes, K. E.; Fawcett, J. W. (2004). "Chondroitin sulphate proteoglycans: Preventing plasticity or protecting the CNS?". Journal of Anatomy. 204 (1): 33–48. doi:10.1111/j.1469-7580.2004.00261.x. PMC 1571240. PMID 14690476.
^Siebert, J. R.; Osterhout, D. J. (2011). "The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes". Journal of Neurochemistry. 119 (1): 176–188. doi:10.1111/j.1471-4159.2011.07370.x. PMID 21848846. S2CID 205623522.
and 30 Related for: Chondroitin sulfate proteoglycan information
Chondroitinsulfateproteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitinsulfate side chain. They are known to be structural...
glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitinsulfate-GlcA-Gal-Gal-Xyl-PROTEIN). The Ser residue is generally in the sequence...
to proteins as part of a proteoglycan. A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and...
A chondroitin is a chondrin derivative. Types include: Chondroitinsulfate Dermatan sulfateChondroitin as a supplement is now commonly used (often in...
Chondroitinsulfateproteoglycan 4, also known as melanoma-associated chondroitinsulfateproteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin...
not been studied until recently. Like the chondroitinsulfateproteoglycans, keratan sulfateproteoglycan (KSPG) production is up regulated in reactive...
mannose-linked sialylated tetrasaccharide and keratan sulfate oligosaccharides in the chondroitinsulfateproteoglycan of brain". J. Biol. Chem. 261 (18): 8237–8242...
(ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitinsulfateproteoglycan 1, is a protein that in humans is encoded...
matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene. Versican is a large chondroitinsulfateproteoglycan with...
supplements such as chondroitinsulfate and methylsulfonylmethane.[citation needed] Glucosamine, along with commonly used chondroitin, is not routinely...
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (HSPG, i.e. Heparan SulfateProteoGlycan) in which...
species include human CSPG4, also known as melanoma-associated chondroitinsulfateproteoglycan (MCSP), Mouse AN2, and Sea urchin ECM3. This single-pass transmembrane...
Chondroitinsulfateproteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene. CSPG5 has been shown to interact with GOPC. GRCh38: Ensembl...
Chondroitinsulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene. A form of mild skeletal dysplasia...
their core disaccharide structures: Heparin/heparan sulfate (HSGAGs) Chondroitinsulfate/dermatan sulfate (CSGAGs) which along with HSGAGs are synthesized...
consisting of either chondroitinsulfate (CS) or dermatan sulfate (DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related...
Molecular Weight Melanoma Associated Antigen, also known as Chondroitinsulfateproteoglycan 4 (CSPG4) which has been the target of immune therapy. In 2009...
Growth Factor Receptor Beta (PDGFR-B), aminopeptidase-N (CD13), chondroitinsulfateproteoglycan 4 (Ng2), or desmin, which makes their identification difficult...
glycosaminoglycan (GAG) chains consisting of either chondroitinsulfate (CS) or dermatan sulfate (DS), with DS being more abundant in most connective...
"Experience-dependent development of perineuronal nets and chondroitinsulfateproteoglycan receptors in mouse visual cortex". Matrix Biology. 32 (6):...
Martin U.K. and AgustaWestland EH101) Melanoma-associated chondroitinsulfateproteoglycan, a tumour marker Member of the Chartered Society of Physiotherapy...
brain. They are largely negatively charged and composed of chondroitinsulfateproteoglycans, molecules that play a key role in development and plasticity...
clues whether to promote or suppress extension of axons. Chondroitinsulfateproteoglycans suppress the extension of axons over the glial scar, a barrier...
number of antigens, including the ganglioside GD3, the NG2 chondroitinsulfateproteoglycan, and the platelet-derived growth factor-alpha receptor subunit...
Global Information