ADAMTS4 information

ADAMTS4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RJP, 3B2Z, 4WK7, 4WKE, 4WKI
Identifiers
Aliases	ADAMTS4, ADAMTS-2, ADAMTS-4, ADMP-1, ADAM metallopeptidase with thrombospondin type 1 motif 4
External IDs	OMIM: 603876; MGI: 1339949; HomoloGene: 36169; GeneCards: ADAMTS4; OMA:ADAMTS4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,199,054 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,088,206 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; gallbladder; ; gastric mucosa; ; left ovary; ; stromal cell of endometrium; ; right ovary; ; C1 segment; ; right auricle; ; smooth muscle tissue; ; tibial nerve;
	Top expressed in
	lumbar subsegment of spinal cord; ; deep cerebellar nuclei; ; epithelium of lens; ; calvaria; ; secondary oocyte; ; lateral geniculate nucleus; ; Region I of hippocampus proper; ; pontine nuclei; ; globus pallidus; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protease binding; peptidase activity; zinc ion binding; protein binding; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	extracellular region; extracellular space; nuclear speck; extracellular matrix; collagen-containing extracellular matrix;
Biological process	skeletal system development; extracellular matrix disassembly; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	9507
	240913
	ENSG00000158859
	ENSMUSG00000006403
	O75173
	Q8BNJ2
	NM_005099; NM_001320336
	NM_172845
	NP_001307265; NP_005090
	NP_766433
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.^[5]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It can degrade aggrecan, a major proteoglycan of cartilage, brevican, a brain-specific extracellular matrix protein, neurocan and versican. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158859 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006403 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Hong W (Feb 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Letters. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.
^ "Entrez Gene: ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158859 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006403 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10094461-5] Tang BL, Hong W (Feb 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Letters. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. S2CID 37955930.

[entrez-6] "Entrez Gene: ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4".

ADAMTS4 information

and 10 Related for: ADAMTS4 information

ADAMTS4

ADAMTS

Thrombospondin

Aggrecanase

Matrix metallopeptidase 13

Brevican

ADAMTS5

Proteases in angiogenesis

MMP17

CYR61