Granzyme B (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells. It is secreted by these cells along with the pore forming protein perforin to mediate apoptosis in target cells.
Granzyme B has also been found to be produced by a wide range of non-cytotoxic cells ranging from basophils and mast cells to smooth muscle cells.[1] The secondary functions of granzyme B are also numerous. Granzyme B has shown to be involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodelling.
Elevated levels of granzyme B are also implicated in a number of autoimmune diseases, several skin diseases, and type 1 diabetes.
^Afonina IS, Cullen SP, Martin SJ (May 2010). "Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B". Immunological Reviews. 235 (1): 105–16. doi:10.1111/j.0105-2896.2010.00908.x. PMID 20536558.
GranzymeB (GrB) is one of the serine protease granzymes most commonly found in the granules of natural killer cells (NK cells) and cytotoxic T cells....
Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death...
unique and parallel to that of GranzymeB, although some substrates such as PARP-1 and lamin B are shared with GranzymeB. Substrates of GzmA include Pro-IL-1β...
GranzymeB is a serine protease that in humans is encoded by the GZMB gene. GranzymeB is expressed by cytotoxic T lymphocytes (CTL) and natural killer...
Regulatory T cells can produce GranzymeB, which in turn can induce apoptosis of effector cells. Regulatory T cells from GranzymeB deficient mice are reported...
protease GranzymeB, cytotoxic T-cells and NK cells are able to induce apoptosis in target cell. SCs produce PI-9 that irreversibly bonds GranzymeB and inhibits...
influence of blood pressure. Other reports have suggested the serine protease granzymeB may contribute to aortic aneurysm rupture through the cleavage of decorin...
the cytotoxic granule protease granzymeB. In doing so, Serpin B9 may protect against inadvertent release of granzymeB and premature or unwanted activation...
angiogenesis, blood coagulation, abolishing detachment activity by GrB (GranzymeB), and tumour metastasis. HS has also been shown to serve as cellular...
cell death through release of a number of molecules, including perforin, granzymeB, and granulysin. Other agents, including tumor necrosis factor alpha and...
granules that contains proteins involved in cell lysis such as perforin and granzymeB. Flow cytometry is also commonly used. Bone marrow involvement in this...
and mice IELs express higher levels of CD103, activation marker CD69, granzymeB and perforin cytolytic granules. CD25 expression is lower in comparison...
IFN-y cytokine and granzymeB secretion in order to assess cytotoxic T-cell responses. Both of these are used for cancer research. With B-cell FluoroSpot...
T-cell can attach itself to a membrane, facilitating the release of granzymeB. GranzymeB perforates the target cell membrane and in turn allows the release...
beta (TGF-β). Another known mechanism is the production of cytotoxic GranzymeB. Bregs also express various inhibitory surface markers such as programmed...
television production company Gamma-ray burst, an astronomical event GranzymeB (GrB), serine protease most commonly found in the granules of NK cells and...
associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis...
collectively termed granzymes and include 4 distinct gene products: granzyme A, granzymeB, granzyme H, and Met-ase, also known as granzyme M. GRCh38: Ensembl...
activity due to impaired expression of associated molecules such as IFN-γ, granzymeB or perforin impaired proliferation in response to antigenic stimulation...
through its association with a protein complex that forms apoptosome, or by granzymeB, or via the death receptor pathways. Autoproteolysis takes place in some...
latter's Fc regions interact with their Fc receptors, releasing perforin and granzymeB to kill the tumor cell. Examples include rituximab, ofatumumab, elotuzumab...
been shown to enhance CD8+ T cell secretion of the cytotoxic molecules GranzymeB and Perforin and potentiate T cell receptor dependent IFNγ secretion....
such as secretion of tumor necrosis factor (TNF)-alpha, secretion of granzymeB, or Fas-Fas ligand interactions. Chemokines are produced by activated...
One mechanism used by TRM to restrict pathogens is the secretion of granzymeB. Stem cell-like memory T cells (TSCM): Those lymphocytes are capable of...
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