Abrin-a structure (PDB: 1ABR). The A chain is shown in blue and the B chain in olive. A single peptide is cleaved into the two chains.
Identifiers
Organism
Abrus precatorius
Symbol
?
CAS number
1393-62-0
UniProt
P11140
Search for
Structures
Swiss-model
Domains
InterPro
Abrin
Identifiers
CAS Number
1393-62-0Y
ChemSpider
none
KEGG
C20068
RTECS number
AA5250000
UNII
6YCF89P8OXY
UN number
3462
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Abrin is an extremely toxic toxalbumin found in the seeds of the rosary pea (or jequirity pea), Abrus precatorius. It has a median lethal dose of 0.7 micrograms per kilogram of body mass when given to mice intravenously (approximately 3.86 times more toxic than ricin, being 2.7 micrograms per kilogram).[1] The median toxic dose for humans ranges from 10 to 1000 micrograms per kilogram when ingested and is 3.3 micrograms per kilogram when inhaled.[2]
Abrin is a ribosome inhibiting protein like ricin, a toxin which can be found in the seeds of the castor oil plant,[3] and pulchellin, a toxin which can be found in the seeds of Abrus pulchellus.[4] Abrin is classed as a "select agent" under U.S. law.
^Gill DM (1982). "Bacterial toxins: a table of lethal amounts". Microbiological Reviews. 46 (1): 86–94. doi:10.1128/MMBR.46.1.86-94.1982. PMC 373212. PMID 6806598.
^Rudolf C Johnson, et al. (March 2009). "Quantification of L-Abrine in Human and Rat Urine: A Biomarker for the Toxin Abrin". Journal of Analytical Toxicology. 33 (2): 77–84. doi:10.1093/jat/33.2.77. PMID 19239732.
^Sadraeian M, Guimaraes GF, Araujo AP, Worthylake DK, LeCour LJ, Pincus SH (2017). "Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope". Scientific Reports. 7 (1): 7579. Bibcode:2017NatSR...7.7579S. doi:10.1038/s41598-017-08037-3. PMC 5548917. PMID 28790381.
Abrin is an extremely toxic toxalbumin found in the seeds of the rosary pea (or jequirity pea), Abrus precatorius. It has a median lethal dose of 0.7 micrograms...
percussion instruments, and which are toxic because of the presence of abrin. Ingestion of a single seed, well chewed, can be fatal to both adults and...
plant (Abrus precatorius). The seeds contain the extremely toxic lectin abrin, whose toxicity is over 30 times that of ricin. These seeds have been used...
disulfide bond. In terms of structure, ricin closely resembles abrin-a, an isomer of abrin. The quaternary structure of ricin is a globular, glycosylated...
offspring of a male mouse immunized against abrin and an untreated female mouse were not immune to abrin. He concluded that the fetus was supplied with...
Ehrlich showed that antibodies form against the plant toxins ricin and abrin, and proposed that these antibodies are responsible for immunity. Ehrlich...
against a foreign body. Ehrlich accustomed mice to the poisons ricin and abrin. After feeding them with small but increasing dosages of ricin he ascertained...
different saccharide binding specificity. Cytotoxic lectins include ricin, abrin, modeccin, volkensin (least toxic, 10 and 40 times less cytotoxic than ricin...
al-Baitar). The Latin botanical Abrus is the parent of the chemical name Abrin; see abrine @ CNRTL.fr. The Arabic لبلاب lablāb means any kind of climbing...
isolated from seeds of the castor oil plant and comprises two protein domains. Abrin from the jequirity pea is similar: One domain is a lectin that binds cell...
Abraham, AK (1975). "On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit"...
Ambrines (French pronunciation: [ɑ̃bʁin]; Picard: Ambrainne) is a commune in the Pas-de-Calais department in northern France. A farming village located...
is very similar to other RIPs, showing the most resemblance to ricin and abrin. Some birds have immunity to the poison and enjoy the berries, especially...
and is now working on the creation of the chemical weapon loaded with abrin by delivering to his former roommate the rosary pea seeds to complete the...
human and animal health, to plant health, or to animal and plant products". Abrin Botulinum neurotoxins* Clostridium perfringens epsilon toxin Conotoxins...
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