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Humoral immunity information


Humoral immunity is the aspect of immunity that is mediated by macromolecules – including secreted antibodies, complement proteins, and certain antimicrobial peptides – located in extracellular fluids. Humoral immunity is named so because it involves substances found in the humors, or body fluids. It contrasts with cell-mediated immunity. Humoral immunity is also referred to as antibody-mediated immunity.

The study of the molecular and cellular components that form the immune system, including their function and interaction, is the central science of immunology. The immune system is divided into a more primitive innate immune system and an acquired or adaptive immune system of vertebrates, each of which contain both humoral and cellular immune elements.

Humoral immunity refers to antibody production and the coinciding processes that accompany it, including: Th2 activation and cytokine production, germinal center formation and isotype switching, and affinity maturation and memory cell generation. It also refers to the effector functions of antibodies, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination.[1]

  1. ^ Janeway Jr CA (2001). Immunobiology (5th ed.). Garland Publishing. ISBN 0-8153-3642-X.

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Humoral immunity

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Humoral immunity is the aspect of immunity that is mediated by macromolecules – including secreted antibodies, complement proteins, and certain antimicrobial...

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Humoral immune deficiency

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Humoral immune deficiencies are conditions which cause impairment of humoral immunity, which can lead to immunodeficiency. It can be mediated by insufficient...

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Passive immunity

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In immunology, passive immunity is the transfer of active humoral immunity of ready-made antibodies. Passive immunity can occur naturally, when maternal...

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Immune system

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19th century, through rapid developments in the study of humoral immunity and cellular immunity. Particularly important was the work of Paul Ehrlich, who...

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Adaptive immune system

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Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens...

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Humorism

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Humorism, the humoral theory, or humoralism, is a system of medicine detailing a supposed makeup and workings of the human body, adopted by Ancient Greek...

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Antibody

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function. The term humoral immunity is often treated as synonymous with the antibody response, describing the function of the immune system that exists...

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Immunoglobulin G

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IgG antibody has two paratopes. Antibodies are major components of humoral immunity. IgG is the main type of antibody found in blood and extracellular...

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Immunodeficiency

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infectious diseases owing to the reduced protection afforded by vaccines. Humoral immune deficiency (including B cell deficiency or dysfunction), with signs...

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Humoral factor

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Humoral factors are factors that are transported by the circulatory system, that is, in blood, and include: Humoral immunity factors in the immune system...

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Lymphocyte

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in the immune system of most vertebrates. Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven...

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Immunology

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saw a battle between "cellular" and "humoral" theories of immunity. According to the cellular theory of immunity, represented in particular by Elie Metchnikoff...

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Streptococcus pneumoniae

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of pneumonia in the late 19th century, and is the subject of many humoral immunity studies.[citation needed] Streptococcus pneumoniae resides asymptomatically...

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Original antigenic sin

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epitopes. Antibody-dependent enhancement Cell mediated immunity Genomic imprinting Humoral immunity Polyclonal response Local optimum Hoskins, T.W.; Davies...

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Passive

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from cash flow received on a regular basis Passive immunity, the transfer of active humoral immunity Passive experience, observation lacking recipricol...

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Mucosal immunology

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susceptibility to infections, and more. The mucosal immune system consists of a cellular component, humoral immunity, and defense mechanisms that prevent the invasion...

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MRNA vaccine

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speed and lower cost of production, the induction of both cellular and humoral immunity, and lack of interaction with the genomic DNA. While some messenger...

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Transmembrane activator and CAML interactor

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cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: B-cell activating...

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CTAG1B

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spontaneous cellular and humoral immune responses in patients with advanced stage tumours. The first reported simultaneous humoral and cellular response...

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Complement receptor

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can also increase risk of certain diseases. Complement system Humoral immunity Immune system Holers VM (29 January 2014). "Complement and its receptors:...

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B cell

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cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may...

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Cortisol

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agents of humoral immunity. A larger number of lymphocytes in the lymph nodes, bone marrow, and skin means the body is increasing its humoral immune response...

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Immunosuppressive drug

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decreases the proliferation of T cells. Glucocorticoids also suppress the humoral immunity, causing B cells to express smaller amounts of IL-2 and IL-2 receptors...

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Glucocorticoid

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the Bcl-2 gene. Glucocorticoids also suppress the humoral immunity, thereby causing a humoral immune deficiency. Glucocorticoids cause B cells to express...

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