ATP2A3 information

ATP2A3
Identifiers
Aliases	ATP2A3, SERCA3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
External IDs	OMIM: 601929; MGI: 1194503; HomoloGene: 69131; GeneCards: ATP2A3; OMA:ATP2A3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,964,464 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,883,870 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; olfactory zone of nasal mucosa; ; spleen; ; mucosa of transverse colon; ; thymus; ; lymph node; ; blood; ; bone marrow cells; ; beta cell; ; appendix;
	Top expressed in
	submandibular gland; ; parotid gland; ; granulocyte; ; islet of Langerhans; ; pyloric antrum; ; crypt of lieberkuhn of small intestine; ; colon; ; left colon; ; thymus; ; tibiofemoral joint;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; P-type calcium transporter activity; metal ion binding; hydrolase activity; ATP binding; P-type proton-exporting transporter activity;
Cellular component	integral component of membrane; nuclear membrane; endoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; platelet dense tubular network membrane; endoplasmic reticulum; nucleus; sarcoplasmic reticulum membrane;
Biological process	regulation of cardiac conduction; ion transport; ion transmembrane transport; calcium ion transmembrane transport; calcium ion transport; cellular calcium ion homeostasis; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	489
	53313
	ENSG00000074370
	ENSMUSG00000020788
	Q93084
	Q64518
NM_005173; NM_174953; NM_174954; NM_174955; NM_174956;
	NM_174957; NM_174958
	NM_001163336; NM_001163337; NM_016745
NP_005164; NP_777613; NP_777614; NP_777615; NP_777616;
	NP_777617; NP_777618
	NP_001156808; NP_001156809; NP_058025
	Wikidata
View/Edit Human	View/Edit Mouse

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.^[5]^[6]

This gene encodes one of the SERCA Ca²⁺-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074370 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020788 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca²⁺-ATPase 3 gene". Biochem J. 318 (2): 689–99. doi:10.1042/bj3180689. PMC 1217674. PMID 8809064.
^ ^a ^b "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074370 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020788 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8809064-5] Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca²⁺-ATPase 3 gene". Biochem J. 318 (2): 689–99. doi:10.1042/bj3180689. PMC 1217674. PMID 8809064.

[entrez-6] "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous".

ATP2A3 information

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