Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Nverify (what is YN ?)
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Chemical compound
Yangonin is one of the six major kavalactones found in the kava plant.[1] It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), and selectivity vs. the CB2 receptor (Ki >10 μM) where it behaves as an agonist. The CB1 receptor affinity of yangonin suggests that the endocannabinoid system might contribute to the complex human psychopharmacology of the traditional kava drink and the anxiolytic preparations obtained from the kava plant.[2]
Like other kavalactones, yangonin has been found to potentiate GABAA receptors.[3] This may contribute to the anxiolytic properties of yangonin and kava as a whole.
Further in vitro studies have also demonstrated yangonin to be an inhibitor of monoamine oxidase,[citation needed] with a moderate preference for isozyme B, which could open the door to a wide range of interactions.
^Malani, Joji (2002-12-03). "Evaluation of the effects of Kava on the Liver" (PDF). Fiji School of Medicine. Retrieved 2009-09-04.
^Ligresti, A.; Villano, R.; Allarà, M.; Ujváry, I. N.; Di Marzo, V. (2012). "Kavalactones and the endocannabinoid system: The plant-derived yangonin is a novel CB1 receptor ligand". Pharmacological Research. 66 (2): 163–169. doi:10.1016/j.phrs.2012.04.003. PMID 22525682.
Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki...
glucose induced cell damage. Several kavalactones (e.g., methysticin and yangonin) affect a group of enzymes involved in metabolism, called the CYP450 system...
of harvest. The kavalactones present are kavain, demethoxyyangonin, and yangonin, which are higher in the roots than in the stems and leaves, with dihydrokavain...
the plant structure, but are most concentrated in the roots and flowers. Yangonin found in the kava plant has significant affinity to the CB1 receptor. Tea...
2012). "Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand". Pharmacological Research. 66 (2): 163–9...
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