Y box binding protein 1 information

YBX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H95
Identifiers
Aliases	YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDs	OMIM: 154030; MGI: 99146; HomoloGene: 88707; GeneCards: YBX1; OMA:YBX1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,703,805 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,151,801 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; gastrocnemius muscle; ; muscle of thigh; ; skeletal muscle tissue; ; left ventricle; ; stromal cell of endometrium;
	Top expressed in
	Ileal epithelium; ; primitive streak; ; tail of embryo; ; abdominal wall; ; medial ganglionic eminence; ; endothelial cell of lymphatic vessel; ; seminiferous tubule; ; choroid plexus of fourth ventricle; ; migratory enteric neural crest cell; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; RNA binding; nucleic acid binding; GTPase binding; double-stranded DNA binding; single-stranded DNA binding; chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; CRD-mediated mRNA stability complex; nuclear membrane; intracellular membrane-bounded organelle; U12-type spliceosomal complex; nucleoplasm; extracellular region; cytoplasmic stress granule; extracellular exosome; nucleus; histone pre-mRNA 3'end processing complex; cytosol; ribonucleoprotein complex;
Biological process	CRD-mediated mRNA stabilization; mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; mRNA processing; transcription by RNA polymerase II; protein localization to cytoplasmic stress granule; transcription, DNA-templated; positive regulation of cell division; positive regulation of transcription by RNA polymerase II; in utero embryonic development; RNA splicing; negative regulation of striated muscle cell differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; cellular response to interleukin-7;
	Sources:Amigo / QuickGO
Orthologs
	4904
	22608
	ENSG00000065978
	ENSMUSG00000028639
	P67809
	P62960
	NM_004559
	NM_011732
	NP_004550
	NP_035862
	Wikidata
View/Edit Human	View/Edit Mouse

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.^[5] YBX1 is an RNA binding protein^[6] that stabilises messenger RNAs modified with N6-methyladenosine.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065978 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028639 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ EntrezGene 4904 YBX1 Y-box binding protein 1
^ Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, et al. (April 2018). "The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level". Nature Communications. 9 (1): 1734. Bibcode:2018NatCo...9.1734K. doi:10.1038/s41467-018-04092-0. PMC 5928080. PMID 29712925.
^ Feng M, Xie X, Han G, Zhang T, Li Y, Li Y, et al. (July 2021). "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner". Blood. 138 (1): 71–85. doi:10.1182/blood.2020009676. PMC 8667054. PMID 33763698.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065978 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028639 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] EntrezGene 4904 YBX1 Y-box binding protein 1

[Kwon_2018-6] Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, et al. (April 2018). "The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level". Nature Communications. 9 (1): 1734. Bibcode:2018NatCo...9.1734K. doi:10.1038/s41467-018-04092-0. PMC 5928080. PMID 29712925.

[7] Feng M, Xie X, Han G, Zhang T, Li Y, Li Y, et al. (July 2021). "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner". Blood. 138 (1): 71–85. doi:10.1182/blood.2020009676. PMC 8667054. PMID 33763698.

Y box binding protein 1 information

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TATA box

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Transcription factor

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