The family of heterochromatin protein 1 (HP1) ("Chromobox Homolog", CBX) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequestration of genes to the nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level, gene repression by heterochromatization of euchromatin, and DNA repair. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all eukaryotic chromosomes with the notable exception of budding yeast, in which a yeast-specific silencing complex of SIR (silent information regulatory) proteins serve a similar function. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a hinge region. HP1 is also found at some euchromatic sites, where its binding can correlate with either gene repression or gene activation. HP1 was originally discovered by Tharappel C James and Sarah Elgin in 1986 as a factor in the phenomenon known as position effect variegation in Drosophila melanogaster.[1][2]
^James TC, Elgin SC (November 1986). "Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene". Molecular and Cellular Biology. 6 (11): 3862–72. doi:10.1128/mcb.6.11.3862. PMC 367149. PMID 3099166.
^Eissenberg JC, James TC, Foster-Hartnett DM, Hartnett T, Ngan V, Elgin SC (December 1990). "Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster". Proceedings of the National Academy of Sciences of the United States of America. 87 (24): 9923–7. Bibcode:1990PNAS...87.9923E. doi:10.1073/pnas.87.24.9923. PMC 55286. PMID 2124708.
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The family of heterochromatinprotein1 (HP1) ("Chromobox Homolog", CBX) consists of highly conserved proteins, which have important functions in the cell...
Heterochromatin is a tightly packed form of DNA or condensed DNA, which comes in multiple varieties. These varieties lie on a continuum between the two...
Constitutive heterochromatin domains are regions of DNA found throughout the chromosomes of eukaryotes. The majority of constitutive heterochromatin is found...
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tri-methylation of this lysine residue facilitates the binding of heterochromatinprotein1 (HP1). Because HP1 and Suv39h1 interact, it is thought the binding...
Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene. The protein is localized at heterochromatin sites, where it mediates...
of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression". Molecular...
Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans. At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent...
Heterochromatinprotein1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene. It has been identified as a novel subtype of the...
located on the X chromosome (Xq13.1-q21.1), in the pericentromeric heterochromatin and binds to heterochromatinprotein1. Studies have shown that ATRX plays...
of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATINPROTEIN1". Nature Genetics. 38 (6): 706–10. doi:10.1038/ng1795. PMID 16682972...
binding site for the recruitment of Swi6 (heterochromatinprotein1 or HP1, another classic heterochromatin marker) which in turn recruits further repressive...
cells. It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support, the nuclear lamina regulates important...
six-cylinder motorcycle made by Toyota from 1978 to 1982 the family of HeterochromatinProtein1 or "Chromobox Homolog" or short CBX, in molecular biology the...
shadow domain include Drosophila and human heterochromatinprotein Su(var)205 (HP1); and mammalian modifier 1 and modifier 2. Chromo shadow domains self-aggregate...
Winters. In Paris, the driving gene encodes a DNA modelling protein ("heterochromatinprotein1 D2" or HP1D2), where the allele of the driving copy fails...
et al. (February 2000). "Identification of heterochromatinprotein1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation...
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and protein) that is enriched in genes, and is often (but not always) under active transcription. Euchromatin stands in contrast to heterochromatin, which...
HP1 or variant, may refer to: HeterochromatinProtein1, an important marker molecule in epigenetic research The postal code for part of Hemel Hempstead...
deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase...
(October 2002). "Association of class II histone deacetylases with heterochromatinprotein1: potential role for histone methylation in control of muscle differentiation"...
Silent Information Regulator (SIR) proteins are involved in regulating gene expression. SIR proteins organize heterochromatin near telomeres, ribosomal DNA...
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