Von Willebrand factor (VWF) (German:[fɔnˈvɪləbʁant]) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic–uremic syndrome.[5] Increased plasma levels in many cardiovascular, neoplastic, metabolic (e.g. diabetes), and connective tissue diseases are presumed to arise from adverse changes to the endothelium, and may predict an increased risk of thrombosis.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000110799 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001930 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sadler JE (1998). "Biochemistry and genetics of von Willebrand factor". Annual Review of Biochemistry. 67: 395–424. doi:10.1146/annurev.biochem.67.1.395. PMID 9759493.
^Shahidi M (2017). "Thrombosis and von Willebrand Factor". Thrombosis and Embolism: From Research to Clinical Practice. Advances in Experimental Medicine and Biology. Vol. 906. pp. 285–306. doi:10.1007/5584_2016_122. ISBN 978-3-319-22107-6. PMID 27628010.
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VonWillebrandfactor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient...
conditions. It arises from a deficiency in the quality or quantity of vonWillebrandfactor (VWF), a multimeric protein that is required for platelet adhesion...
13)—also known as vonWillebrandfactor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves vonWillebrandfactor (vWf), a large...
from vonWillebrandfactor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX...
made major contributions to hematology. Von Willebrand disease and vonWillebrandfactor are named after him. He also researched metabolism, obesity and...
The vonWillebrandfactor type A (vWA) domain is a protein domain named after its occurrence in vonWillebrandfactor (vWF), a large multimeric glycoprotein...
ADAMTS13. This results in decreased break down of large multimers of vonWillebrandfactor (vWF) into smaller units. Less commonly TTP is inherited, known...
forming against a clotting factor. Other types include haemophilia C, which occurs due to low levels of factor XI, VonWillebrand disease, which occurs due...
VonWillebrandfactor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins...
Willebrand or Willebrands may refer to: VonWillebrand disease, a hereditary coagulation abnormality disease VonWillebrandfactor, a blood glycoprotein...
glycoprotein IIb/IIIa) to extracellular matrix proteins (e.g. vonWillebrandfactor) on cell membranes of damaged endothelial cells and exposed collagen...
Through an unknown mechanism, the antibiotic ristocetin causes vonWillebrandfactor to bind the platelet receptor glycoprotein Ib (GpIb), so when ristocetin...
secretion of coagulation and aggregation inhibitors and instead secrete vonWillebrandfactor, which initiates the maintenance of hemostasis after injury. These...
the dog should not be bred. This disease is caused by a lack of vonWillebrandfactor which plays a role in the clotting process of blood. This can cause...
ligands include syndecan-1, glycosaminoglycans, vonWillebrandfactor, and factor VIII-vonWillebrandfactor complex. OPG has been identified as having a...
decreased release of the endothelium-derived relaxing factor and increased the release of vonWillebrandfactor (vWF), leading to general activation of the coagulation...
control bleeding in adults with vonWillebrand disease (an inherited bleeding disorder). It is a recombinant vonWillebrandfactor. The most common adverse reactions...
release of vonWillebrandfactor and factor VIII from the endothelial cells. Because vonWillebrandfactor helps stabilize circulating levels of factor VIII...
group is associated with reduced levels of vonWillebrandfactor – because of increased clearance – and factor VIII, which is related to thrombotic risk...
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