cysteine-type endopeptidase inhibitor activity involved in apoptotic process
neurohypophyseal hormone activity
signaling receptor binding
V1A vasopressin receptor binding
V1B vasopressin receptor binding
neuropeptide hormone activity
Cellular component
extracellular region
cytosol
clathrin-coated vesicle membrane
extracellular space
secretory granule
dendrite
Biological process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
vasoconstriction
negative regulation of release of cytochrome c from mitochondria
ERK1 and ERK2 cascade
water transport
cell-cell signaling
negative regulation of apoptotic process
protein kinase C signaling
generation of precursor metabolites and energy
positive regulation of peptidyl-serine phosphorylation
positive regulation of gene expression
renal water homeostasis
signal transduction
apoptotic process
membrane organization
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
maternal aggressive behavior
positive regulation of systemic arterial blood pressure
positive regulation of cytosolic calcium ion concentration
negative regulation of female receptivity
grooming behavior
locomotory behavior
positive regulation of cell population proliferation
positive regulation of glutamate secretion
response to organic cyclic compound
positive regulation of cell growth
positive regulation of prostaglandin biosynthetic process
positive regulation of cellular pH reduction
response to testosterone
response to nicotine
social behavior
regulation of renal sodium excretion
hyperosmotic salinity response
maternal behavior
penile erection
response to ethanol
positive regulation of vasoconstriction
multicellular organismal water homeostasis
negative regulation of transmission of nerve impulse
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
551
11998
Ensembl
ENSG00000101200
ENSMUSG00000037727
UniProt
P01185
P35455
RefSeq (mRNA)
NM_000490
NM_009732
RefSeq (protein)
NP_000481
NP_033862
Location (UCSC)
Chr 20: 3.08 – 3.08 Mb
Chr 2: 130.42 – 130.42 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin,[5] is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus,[6] and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure.[7][8][9]
A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress.[10]
Vasopressin induces differentiation of stem cells into cardiomyocytes and promotes heart muscle homeostasis.[11]
It has a very short half-life, between 16 and 24 minutes.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000101200 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037727 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Anderson DA (2012). Dorland's Illustrated Medical Dictionary (32nd ed.). Elsevier. ISBN 978-1-4160-6257-8.
^Sukhov RR, Walker LC, Rance NE, Price DL, Young WS 3rd (1993). "Vasopressin and oxytocin gene expression in the human hypothalamus". Journal of Comparative Neurology. 337 (2): 295–306. doi:10.1002/cne.903370210. PMC 9883978. PMID 8277003. S2CID 35174328.
^Marieb E (2014). Anatomy & physiology. Glenview, IL: Pearson Education, Inc. ISBN 978-0-321-86158-0.
^Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications" (PDF). In Lajtha A, Lim R (eds.). Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides (3rd ed.). Berlin: Springer. pp. 573–607. ISBN 978-0-387-30348-2.
^ abBabar SM (October 2013). "SIADH associated with ciprofloxacin". The Annals of Pharmacotherapy. 47 (10): 1359–63. doi:10.1177/1060028013502457. PMID 24259701. S2CID 36759747.
^Insel TR (March 2010). "The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior". Neuron. 65 (6): 768–79. doi:10.1016/j.neuron.2010.03.005. PMC 2847497. PMID 20346754.
^Costa A, Rossi E, Scicchitano BM, Coletti D, Moresi V, Adamo S (September 2014). "Neurohypophyseal Hormones: Novel Actors of Striated Muscle Development and Homeostasis". review. European Journal of Translational Myology. 24 (3): 3790. doi:10.4081/bam.2014.3.217. PMC 4756744. PMID 26913138.
Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a...
The actions of vasopressin are mediated by stimulation of tissue-specific G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified...
Diabetes insipidus (DI), alternately called arginine vasopressin deficiency (AVP-D) or arginine vasopressin resistance (AVP-R), is a condition characterized...
Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for vasopressin...
Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin. AVPR2 belongs...
A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors. Most commonly VRAs are used in the treatment...
a site for the secretion of neurohypophysial hormones (oxytocin and vasopressin) directly into the blood. The hypothalamic–neurohypophyseal system is...
the C-terminus of pre-pro-hormone of arginine vasopressin, neurophysin II and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic hormone...
of vasopressin due to their actions being associated with the hormones testosterone and oestrogen. Oxytocin elicits social bonding, and vasopressin produces...
Vasopressin analogues are chemicals similar in function but not necessarily similar in structure to vasopressin (ADH), such as desmopressin. Desmopressin...
childbirth in patients with complications. By the 1920s, oxytocin and vasopressin had been isolated from pituitary tissue and given their current names...
Vasopressin V1b receptor (V1BR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1B is a protein that in humans is encoded...
Nephrogenic diabetes insipidus, recently renamed as arginine vasopressin resistance (AVP-R) and also previously known as renal diabetes insipidus, is...
pituitary. These projecting neurons secrete oxytocin and a smaller amount of vasopressin, otherwise the nucleus also secretes corticotropin-releasing hormone...
contains about 3,000 neurons. The cell bodies produce the peptide hormone vasopressin, which is also known as anti-diuretic hormone (ADH), and the peptide...
The arginine vasopressin gene (AVP) is a gene whose product is proteolytically cleaved to produce vasopressin (also known as antidiuretic hormone or ADH)...
each works in a distinct way. Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion...
arginine vasopressin deficiency (AVP-D), is a form of diabetes insipidus that is due to a lack of vasopressin (ADH) production in the brain. Vasopressin acts...
appears to be safe to use during pregnancy. It is a synthetic analogue of vasopressin, the hormone that plays roles in the control of the body's osmotic balance...
Magnocellular neurons: Antidiuretic hormone (ADH, also known as vasopressin and arginine vasopressin AVP), the majority of which is released from the supraoptic...
vasoconstriction. Vasopressin regulates the body's retention of water by increasing water reabsorption in the collecting ducts of the kidney nephron. Vasopressin increases...
of vasopressin by the secondary messenger system. Vasopressin levels are reduced after the ingestion of alcohol. The lower levels of vasopressin from...
of the hypothalamus produce neurohypophysial hormones, oxytocin and vasopressin. These hormones are released into the blood in the posterior pituitary...
endogenous antidiuretics are antidiuretic hormone (ADH; also called vasopressin) and oxytocin. Both of those are also used exogenously as medications...
Although it is stored in neurosecretory granules with vasopressin and released with vasopressin into the bloodstream, its biological action is unclear...
reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone). There are several components of the collecting...
stimulate the vasopressin receptor 2 at the kidney (the site of ADH action); or inherited mutations leading to a gain of function of the vasopressin-2 receptor...