adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of systemic arterial blood pressure by vasopressin
activation of adenylate cyclase activity
response to peptide
cellular response to hormone stimulus
positive regulation of vasoconstriction
renal water homeostasis
positive regulation of protein ubiquitination
signal transduction
membrane organization
G protein-coupled receptor signaling pathway
positive regulation of gene expression
positive regulation of systemic arterial blood pressure
I-kappaB kinase/NF-kappaB signaling
positive regulation of cell population proliferation
telencephalon development
response to cytokine
negative regulation of urine volume
negative regulation of renal sodium excretion
positive regulation of blood pressure
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
554
12000
Ensembl
ENSG00000126895
ENSMUSG00000031390
UniProt
P30518
O88721
RefSeq (mRNA)
NM_000054 NM_001146151
NM_001276298 NM_001276299 NM_019404
RefSeq (protein)
NP_000045 NP_001139623
NP_001263227 NP_001263228 NP_062277
Location (UCSC)
Chr X: 153.9 – 153.91 Mb
Chr X: 72.94 – 72.94 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin.[5] AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the Gs type of G proteins, which stimulate adenylate cyclase.
AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney in vascular endothelium.[6] Stimulation causes the release of von Willebrand factor and factor VIII from the endothelial cells.[6] Because von Willebrand factor helps stabilize circulating levels of factor VIII, the vasopressin analog desmopressin can be used to stimulate the AVPR2 receptor and increase levels of circulating factor VIII. This is useful in the treatment of hemophilia A as well as Von Willebrand disease.
In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease nephrogenic diabetes insipidus (NDI) results.
^ abcGRCh38: Ensembl release 89: ENSG00000126895 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031390 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^van den Ouweland AM, Knoop MT, Knoers VV, Markslag PW, Rocchi M, Warren ST, Ropers HH, Fahrenholz F, Monnens LA, van Oost BA (Aug 1992). "Colocalization of the gene for nephrogenic diabetes insipidus (DIR) and the vasopressin type 2 receptor gene (AVPR2) in the Xq28 region". Genomics. 13 (4): 1350–2. doi:10.1016/0888-7543(92)90067-3. PMID 1324225.
^ abJackson EK (2018). "Drugs Affecting Renal Excretory Function". In: Brunton LL, Hilal-Dandan R, Knollmann BC. eds. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e New York, NY: McGraw-Hill.
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