VAV1 information

VAV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Identifiers
Aliases	VAV1, VAV, vav guanine nucleotide exchange factor 1
External IDs	OMIM: 164875; MGI: 98923; HomoloGene: 3961; GeneCards: VAV1; OMA:VAV1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,857,366 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,635,031 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; bone marrow cells; ; lymph node; ; appendix; ; palpebral conjunctiva; ; trabecular bone; ; amniotic fluid; ; thymus;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; thymus; ; interventricular septum; ; spleen; ; blood; ; bone marrow; ; entorhinal cortex; ; ankle joint; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; DNA-binding transcription factor activity; metal ion binding; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine residue binding;
Cellular component	cytosol; cell-cell junction; plasma membrane;
Biological process	regulation of cell size; intracellular signal transduction; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of GTPase activity; T cell costimulation; neutrophil chemotaxis; reactive oxygen species metabolic process; platelet activation; Fc-epsilon receptor signaling pathway; positive regulation of GTPase activity; T cell differentiation; vascular endothelial growth factor receptor signaling pathway; immune response; phagocytosis; positive regulation of apoptotic process; integrin-mediated signaling pathway; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of natural killer cell mediated cytotoxicity; T cell activation; positive regulation of cell adhesion; regulation of transcription, DNA-templated; phosphatidylinositol phosphate biosynthetic process; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; positive regulation of protein kinase B signaling; cytokine-mediated signaling pathway; positive regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7409
	22324
	ENSG00000141968
	ENSMUSG00000034116
	P15498
	P27870
	NM_001258206; NM_001258207; NM_005428
	NM_001163815; NM_001163816; NM_011691
	NP_001245135; NP_001245136; NP_005419
	NP_001157287; NP_001157288; NP_035821
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141968 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034116 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D (February 1998). "Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav". Science. 279 (5350): 558–60. Bibcode:1998Sci...279..558H. doi:10.1126/science.279.5350.558. PMID 9438848.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141968 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034116 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9438848-5] Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D (February 1998). "Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav". Science. 279 (5350): 558–60. Bibcode:1998Sci...279..558H. doi:10.1126/science.279.5350.558. PMID 9438848.

VAV1 information

and 21 Related for: VAV1 information

VAV1

Guanine nucleotide exchange factor

VAV2

T cell

SH2 domain

S100B

Janus kinase 2

GRB2

Scaffold protein

Pleckstrin homology domain

NKG2D

MAPK1

Genetic redundancy

Calponin homology domain

Ku70

PLCG1

C1 domain

Monomorphic epitheliotropic intestinal T cell lymphoma

RTKN

ARHGDIB

RhoGEF domain