negative regulation of tumor necrosis factor production
positive regulation of protein kinase B signaling
viral process
positive regulation of cytokine-mediated signaling pathway
cellular response to interferon-alpha
forebrain cell migration
viral entry into host cell
negative regulation of dendritic cell apoptotic process
protein phosphorylation
cellular response to extracellular stimulus
enzyme linked receptor protein signaling pathway
positive regulation of pinocytosis
negative regulation of neuron apoptotic process
vagina development
ovulation cycle
innate immune response
blood vessel remodeling
cell maturation
dendritic cell differentiation
platelet activation
cell differentiation
immune system process
inflammatory response
neuron migration
phosphorylation
cellular response to hydrogen peroxide
animal organ regeneration
phagocytosis
peptidyl-tyrosine phosphorylation
negative regulation of cytokine production
neutrophil clearance
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
Wnt signaling pathway
cell migration
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
558
26362
Ensembl
ENSG00000167601
ENSMUSG00000002602
UniProt
P30530
Q00993
RefSeq (mRNA)
NM_001278599 NM_001699 NM_021913
NM_001190974 NM_001190975 NM_009465
RefSeq (protein)
NP_001265528 NP_001690 NP_068713
NP_001177903 NP_001177904 NP_033491
Location (UCSC)
Chr 19: 41.22 – 41.26 Mb
Chr 7: 25.46 – 25.49 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene.[5][6] The gene was initially designated as UFO, in allusion to the unidentified function of this protein.[7] However, in the years since its discovery, research into AXL's expression profile and mechanism has made it an increasingly attractive target, especially for cancer therapeutics. In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers.[8]
AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000167601 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002602 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, et al. (Oct 1991). "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase". Molecular and Cellular Biology. 11 (10): 5016–31. doi:10.1128/mcb.11.10.5016. PMC 361494. PMID 1656220.
^"Entrez Gene: AXL AXL receptor tyrosine kinase".
^Janssen JW, Schulz AS, Steenvoorden AC, Schmidberger M, Strehl S, Ambros PF, et al. (1991). "A novel putative tyrosine kinase receptor with oncogenic potential". Oncogene. 6 (11): 2113–20. PMID 1834974.
^Davidsen KT, Haaland GS, Lie MK, Lorens JB, Engelsen AS (2017). "The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance". In Akslen L, Watnick R (eds.). Biomarkers of the Tumor Microenvironment. Cham: Springer. pp. 351–376. ISBN 978-3-319-39147-2.
^Miao YR, Rankin EB, Giaccia AJ (March 2024). "Therapeutic targeting of the functionally elusive TAM receptor family". Nature Reviews. Drug Discovery. 23 (3): 201–217. doi:10.1038/s41573-023-00846-8. PMID 38092952.
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