Anaplastic lymphoma kinase information

ALK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KUP, 2KUQ, 2XB7, 2XBA, 2XP2, 2YFX, 2YHV, 2YJR, 2YJS, 2YS5, 2YT2, 3AOX, 3L9P, 3LCS, 3LCT, 4ANL, 4ANQ, 4ANS, 4CCB, 4CCU, 4CD0, 4CLI, 4CLJ, 4CMO, 4CMT, 4CMU, 4CNH, 4CTB, 4CTC, 4DCE, 4FNW, 4FNX, 4FNY, 4FNZ, 4FOB, 4FOD, 4JOA, 4MKC, 4TT7, 4Z55, 5FTO, 5AAB, 5AAA, 5J7H, 5AA9, 5IUH, 5IUI, 5IMX, 5FTQ, 5A9U, 5IUG, 5AA8, 5AAC
Identifiers
Aliases	ALK, CD246, NBLST3, anaplastic lymphoma receptor tyrosine kinase, ALK receptor tyrosine kinase, ALK (gene), ALK1
External IDs	OMIM: 105590 MGI: 103305 HomoloGene: 68387 GeneCards: ALK
Gene location (Human)
Chr.	Chromosome 2 (human)
End	29,921,586 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	72,911,622 bp
RNA expression pattern
	Top expressed in
	sperm; ; ventral tegmental area; ; superior vestibular nucleus; ; internal globus pallidus; ; subthalamic nucleus; ; Brodmann area 23; ; inferior ganglion of vagus nerve; ; middle temporal gyrus; ; trigeminal ganglion; ; spinal ganglia;
	Top expressed in
	inferior ganglion of vagus nerve; ; endolymphatic sac; ; external carotid artery; ; Jacobson's organ; ; entorhinal cortex; ; optic chiasm; ; posterior semicircular canal; ; sublingual gland; ; inferior olivary nucleus; ; Greater petrosal nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; NF-kappaB-inducing kinase activity; protein binding; identical protein binding; ATP binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity;
Cellular component	integral component of membrane; membrane; extracellular exosome; integral component of plasma membrane; intracellular anatomical structure; plasma membrane; protein-containing complex; receptor complex;
Biological process	regulation of apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; protein phosphorylation; positive regulation of NF-kappaB transcription factor activity; cell population proliferation; protein autophosphorylation; signal transduction; neuron development; peptidyl-tyrosine phosphorylation; NIK/NF-kappaB signaling; phosphorylation; brain development; hippocampus development; adult behavior; swimming behavior; regulation of cell population proliferation; regulation of dopamine receptor signaling pathway; response to environmental enrichment; regulation of neuron differentiation; positive regulation of dendrite development;
	Sources:Amigo / QuickGO
Orthologs
	238
	11682
	ENSG00000171094
	ENSMUSG00000055471
	Q9UM73
	P97793
	NM_004304; NM_001353765
	NM_007439
	NP_004295; NP_001340694
	NP_031465
	Wikidata
View/Edit Human	View/Edit Mouse

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171094 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055471 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, et al. (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.
^ "Entrez Gene: ALK anaplastic lymphoma kinase (Ki-1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171094 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055471 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8122112-5] Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, et al. (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.

[entrez-6] "Entrez Gene: ALK anaplastic lymphoma kinase (Ki-1)".

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