PTK2 information

PTK2
Available structures
PDB	Ortholog search: H0YB16 PDBe H0YB16 RCSB
List of PDB id codes
	4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU6, 4GU9, 4I4E, 4I4F, 4K8A, 4K9Y, 4KAB, 4KAO, 4NY0
Identifiers
Aliases	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pFAK, CT28129, CG10023, Fak56D, DmFAK
External IDs	OMIM: 600758; MGI: 95481; HomoloGene: 7314; GeneCards: PTK2; OMA:PTK2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	19,437,259 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	73,423,280 bp
RNA expression pattern
	Top expressed in
	ovary; ; testicle; ; testicle; ; ovary; ; ovary; ; antenna; ; gut; ; ovary; ; antenna; ; gut;
	Top expressed in
	left lung lobe; ; Gonadal ridge; ; dermis; ; medullary collecting duct; ; tail of embryo; ; dentate gyrus of hippocampal formation granule cell; ; mandibular prominence; ; human fetus; ; maxillary prominence; ; prefrontal cortex;
	More reference expression data
	; ;
	37233/ More reference expression data
Gene ontology
Molecular function	SH2 domain binding; kinase activity; signaling receptor binding; ATP binding; protein kinase activity; JUN kinase binding; non-membrane spanning protein tyrosine kinase activity; transferase activity; protein binding; protein kinase binding; nucleotide binding; actin binding; protein tyrosine kinase activity; protein phosphatase binding;
Cellular component	cytoplasm; cytosol; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; microtubule organizing center; cytoskeleton; nucleus; stress fiber; apical plasma membrane; lamellipodium; plasma membrane; cell cortex; cell junction; dendritic spine; adherens junction;
Biological process	regulation of protein phosphorylation; positive regulation of protein phosphorylation; regulation of cell adhesion mediated by integrin; placenta development; vasculogenesis; protein phosphorylation; vascular endothelial growth factor receptor signaling pathway; growth hormone receptor signaling pathway; blood vessel development; regulation of osteoblast differentiation; angiogenesis; transforming growth factor beta receptor signaling pathway; cellular response to transforming growth factor beta stimulus; positive regulation of protein kinase B signaling; Fc-gamma receptor signaling pathway involved in phagocytosis; cell motility; regulation of GTPase activity; signal complex assembly; regulation of epithelial cell migration; negative regulation of axonogenesis; regulation of endothelial cell migration; establishment of cell polarity; regulation of focal adhesion assembly; phosphorylation; netrin-activated signaling pathway; negative regulation of synapse assembly; extracellular matrix organization; negative regulation of apoptotic process; neuron migration; positive regulation of ubiquitin-dependent protein catabolic process; regulation of cell shape; integrin-mediated signaling pathway; regulation of substrate adhesion-dependent cell spreading; negative regulation of organ growth; microtubule cytoskeleton organization; negative regulation of anoikis; positive regulation of protein kinase activity; negative regulation of cell-cell adhesion; positive regulation of cell migration; ephrin receptor signaling pathway; heart morphogenesis; MAPK cascade; axon guidance; positive regulation of phosphatidylinositol 3-kinase activity; multicellular organism development; regulation of cell population proliferation; positive regulation of cell population proliferation; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of cytoskeleton organization; endothelial cell migration; central nervous system neuron axonogenesis; innate immune response; peptidyl-tyrosine phosphorylation; epidermal growth factor receptor signaling pathway; protein autophosphorylation; nuclear migration; negative regulation of autophagy; positive regulation of cardiac muscle hypertrophy; peptidyl-tyrosine autophosphorylation; cell differentiation; regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5747,37233; 5747,37233
	14083
	ENSG00000169398; FBgn0020440
	ENSMUSG00000022607
	Q05397
	P34152
NM_001199649; NM_005607; NM_153831; NM_001316342; NM_001144246;
	NM_001144247; NM_001169736; NM_079069; NM_166352; NM_166353
	NM_001130409; NM_007982; NM_001358045; NM_001358046
NP_001186578; NP_001303271; NP_005598; NP_722560; NP_001339623;
	NP_001339624; NP_001339625; NP_001339626; NP_001339627; NP_001339628; NP_001339629; NP_001339630; NP_001339631; NP_001339632; NP_001339633; NP_001339634; NP_001339635; NP_001339636; NP_001339637; NP_001339638; NP_001339639; NP_001339640; NP_001339641; NP_001339642; NP_001339643; NP_001339644; NP_001339645; NP_001339646; NP_001339647; NP_001339648; NP_001339649; NP_001339650; NP_001339651; NP_001339652; NP_001339653; NP_001339654; NP_001339655; NP_001339656; NP_001339657; NP_001339658; NP_001339659; NP_001339660; NP_001339661; NP_001339662; NP_001339663; NP_001339664; NP_001339665; NP_001339666; NP_001339667; NP_001339668; NP_001339669; NP_001339670; NP_001339671; NP_001339672; NP_001339673; NP_001339674; NP_001339675; NP_001339676; NP_001339677; NP_001339678; NP_001339679; NP_001339680; NP_001339681
	NP_032008; NP_001344974; NP_001344975
	Wikidata
View/Edit Human	View/Edit Mouse

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.^[4] PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around).^[5] It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022607 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ André E, Becker-André M (January 1993). "Expression of an N-terminally truncated form of human focal adhesion kinase in brain". Biochemical and Biophysical Research Communications. 190 (1): 140–7. doi:10.1006/bbrc.1993.1022. PMID 8422239.
^ Blackshaw SE, Dow JK, Lackie JM (1999). The dictionary of cell and molecular biology (3rd ed.). San Diego: Academic Press. ISBN 978-0-12-432565-4.
^ Chan KT, Cortesio CL, Huttenlocher A (2009). "FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion". The Journal of Cell Biology. 185 (2): 357–70. doi:10.1083/jcb.200809110. PMC 2700377. PMID 19364917.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000022607 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8422239-4] André E, Becker-André M (January 1993). "Expression of an N-terminally truncated form of human focal adhesion kinase in brain". Biochemical and Biophysical Research Communications. 190 (1): 140–7. doi:10.1006/bbrc.1993.1022. PMID 8422239.

[isbn0-12-432565-3-5] Blackshaw SE, Dow JK, Lackie JM (1999). The dictionary of cell and molecular biology (3rd ed.). San Diego: Academic Press. ISBN 978-0-12-432565-4.

[pmid19364917-6] Chan KT, Cortesio CL, Huttenlocher A (2009). "FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion". The Journal of Cell Biology. 185 (2): 357–70. doi:10.1083/jcb.200809110. PMC 2700377. PMID 19364917.

PTK2 information

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