A thymocyte is an immune cell present in the thymus, before it undergoes transformation into a T cell.[1] Thymocytes are produced as stem cells in the bone marrow and reach the thymus via the blood.
Thymopoiesis describes the process which turns thymocytes into mature T cells according to either negative or positive selection. This selection process is vitally important in shaping the population of thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens but remain tolerant towards the body's own antigens. Positive selection selects cells which are able to bind MHC class I or II molecules with at least a weak affinity. This eliminates (by a process called "death by neglect") those T cells which would be non-functional due to an inability to bind MHC. Negative selection destroys thymocytes with a high affinity for self peptides or MHC. This eliminates cells which would direct immune responses towards self-proteins in the periphery. Negative selection is not 100% effective, and some autoreactive T cells escape and are released into the circulation. Additional mechanisms of peripheral tolerance exist to silence these cells, but if these fail, autoimmunity may arise.
A thymocyte is an immune cell present in the thymus, before it undergoes transformation into a T cell. Thymocytes are produced as stem cells in the bone...
T cells, the thymocytes must undergo multiple DN stages as well as positive selection and negative selection. Double negative thymocytes can be identified...
made up of immature T cells called thymocytes, as well as lining cells called epithelial cells which help the thymocytes develop. T cells that successfully...
by TEC network filled with thymocytes (blood cell precursors of T cells) in different developing stages. TECs and thymocytes are the most important components...
Dinitrotoluene, a chemical precursor to TNT Double-negative T cell, a thymocyte in an early stage of development Dysembryoplastic neuroepithelial tumour...
immunosuppressive drugs—typically either anti-lymphocyte globulin or anti-thymocyte globulin—combined with corticosteroids, chemotherapy, and ciclosporin...
dendritic cells, and B lymphocytes, and provide signals essential for thymocyte development and the homeostasis of the thymic stroma. The thymus is a...
needed] Anti-thymocyte globulin, an immunosuppressive agent that selectively destroys T lymphocytes is being studied for use in CIDP. Anti-thymocyte globulin...
epithelium which is often considered an epithelial organ. T cells mature from thymocytes, proliferate, and undergo a selection process in the thymic cortex before...
cortico-medullary junction. They have their own nucleus and are known to internalize thymocytes through extensions of plasma membrane. The cell surfaces of TNCs and their...
2014). "Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)". Nature Reviews. Immunology. 14 (6): 377–91. doi:10...
"Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis". FASEB Journal. 16 (7): 727–729. doi:10.1096/fj...
(2014-05-16). "Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)". Nature Reviews Immunology. 14 (6): 377–391. doi:10...
thyroid gland injuries (including hepatocarcinoma),[citation needed] and thymocyte apoptosis. Other effects of PCBs in animals include changes in the immune...
Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX drives T-cell exhaustion...
thymus. So many thymocytes (T cells) die during the maturation process because there is intensive screening to make sure each thymocyte has the ability...
cells, B-lymphocytes (through surface immunoglobulins), fibroblasts, rat thymocytes, human fetal (but not adult) intestinal epithelial cells, and adipocytes...
with NT-4. The brain-derived neurotrophic factor/TrkB system promotes thymocyte survival, as studied in the thymus of mice. Other experiments suggest...
Hiyane, young noble Gundam Build Divers as Ron Cells at Work! as Immature thymocyte Radiant as Mister Bobley Cardfight!! Vanguard as Battlefield Storm Sagramore...
further differentiation. Skin Langerhans cells express CD1a, as do cortical thymocytes (cells of the cortex of the thymus gland). They also express S-100, and...
murine thymocytes: a flow cytometry study of thymocyte subset distribution and of intracellular free Ca++ increase upon activation. Murine thymocytes and...
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