Lectin (carbohydrate-binding protein) originally extracted from the jack-bean
"ConA" redirects here. For other uses, see Cona.
Concanavalin A
Crystallographic structure of a tetramer of jack bean concanavalin A (the monomers are colored cyan, green, red, and magenta respectively). Calcium (gold) and manganese cations (grey) are depicted as spheres.[1]
Identifiers
Organism
Canavalia ensiformis (jackbean)
Symbol
ConA
PDB
3CNA
UniProt
P81461
Search for
Structures
Swiss-model
Domains
InterPro
Concanavalin A (ConA) is a lectin (carbohydrate-binding protein) originally extracted from the jack-bean (Canavalia ensiformis). It is a member of the legume lectin family. It binds specifically to certain structures found in various sugars, glycoproteins, and glycolipids, mainly internal and nonreducing terminal α-D-mannosyl and α-D-glucosyl groups.[2][3] Its physiological function in plants, however, is still unknown. ConA is a plant mitogen, and is known for its ability to stimulate mouse T-cell subsets giving rise to four functionally distinct T cell populations, including precursors to regulatory T cells;[4] a subset of human suppressor T-cells is also sensitive to ConA.[4] ConA was the first lectin to be available on a commercial basis, and is widely used in biology and biochemistry to characterize glycoproteins and other sugar-containing entities on the surface of various cells.[5] It is also used to purify glycosylated macromolecules in lectin affinity chromatography,[6] as well as to study immune regulation by various immune cells.[4]
^PDB: 3CNA; Hardman KD, Ainsworth CF (December 1972). "Structure of concanavalin A at 2.4-A resolution". Biochemistry. 11 (26): 4910–4919. doi:10.1021/bi00776a006. PMID 4638345.
^Goldstein, Irwin J.; Poretz, Ronald D. (2012). "Isolation, physicochemical characterization, and carbohydrate-binding specificity of lectins". In Liener, Irvin E.; Sharon, Nathan; Goldstein, Irwin J. (eds.). The Lectins Properties, Functions and Applications in Biology and Medicine. Elsevier. pp. 33–247. ISBN 978-0-323-14444-5.
^Sumner JB, Gralën N, Eriksson-Quensel IB (April 1938). "The Molecular Weights of Urease, Canavalin, Concanavalin a and Concanavalin B". Science. 87 (2261): 395–396. Bibcode:1938Sci....87..395S. doi:10.1126/science.87.2261.395. PMID 17746464.
^ abcDwyer JM, Johnson C (November 1981). "The use of concanavalin A to study the immunoregulation of human T cells". Clinical and Experimental Immunology. 46 (2): 237–249. PMC 1536405. PMID 6461456.
^Schiefer HG, Krauss H, Brunner H, Gerhardt U (December 1975). "Ultrastructural visualization of surface carbohydrate structures on mycoplasma membranes by concanavalin A". Journal of Bacteriology. 124 (3): 1598–1600. doi:10.1128/JB.124.3.1598-1600.1975. PMC 236075. PMID 1104592.
^GE Healthcare Life Sciences, Immobilized lectin Archived 2012-03-03 at the Wayback Machine[full citation needed]
ConcanavalinA (ConA) is a lectin (carbohydrate-binding protein) originally extracted from the jack-bean (Canavalia ensiformis). It is a member of the...
called feijão-de-porco ("pig bean"). It is also the source of concanavalinA. C. ensiformis is a twining plant up to 1 metre (3.3 ft) in height. It has deep...
A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). Mitogenesis is...
blood grouping and research. Lectins from legume plants, such as PHA or concanavalinA, have been used widely as model systems to understand the molecular...
Secondary metabolism produces a large number of specialized compounds (estimated 200,000) that do not aid in the growth and development of plants but...
(3D) shape. In 1979, the first pair of circularly permuted proteins – concanavalinA and lectin – were discovered; over 2000 such proteins are now known...
formed of four units, that are the same (homotetramer), i.e. as in ConcanavalinA or different (heterotetramer), i.e. as in hemoglobin. Hemoglobin has...
differentiation and growth of a pure population of mouse mast cells has been carried out using conditioned medium derived from concanavalinA-stimulated splenocytes...
supplementation alters macrophage phagocytosis and lymphocyte response to concanavalinA: a study in alloxan-induced diabetic rats". Cell Biochemistry and Function...
concanavalinA (Con A). A study done by the American Psychological Association did an experiment on rats, where they applied electrical shocks to a rat...
integration of tangible goods beyond Earth's atmosphere (or more generally, outside a planetary atmosphere), involving the transformation of raw or recycled materials...
the production of the Th1 cytokines IL-2 and IFN-γ irrespective of concanavalin-A stimulation, whereas the production of the Th2 cytokines IL-4 and IL-5...
functional mechanisms which use selective glucose-binding proteins (e.g. concanavalinA) as a receptor. Furthermore, methods were developed which indirectly detect...
Confounding Results as It Did in Studies of JNK2 in Acetaminophen and ConcanavalinA Liver Injury". Chemical Research in Toxicology. 24 (6): 794–796. doi:10...
chromatography is a form of affinity chromatography where lectins are used to separate components within the sample. Lectins, such as concanavalinA are proteins...
molecules occur in a measurable concentration. In case of glucose, for instance, concanavalinA may function as affinity receptor exhibiting a binding constant...
Cona, a vacuum coffee maker designed by Abram Games ConA, ConcanavalinA, a lectin protein Search for "cona" , "c-ona", "con-a", "co-na", or "c-o-n-a" on...
railway operation in winter (catenary)_ OCS accident case analysis". Concanavalin Library. 2020-02-29. Archived from the original on 2022-07-02. Retrieved...
fold. Furthermore, CB can intensify pinocytosis, which is induced by concanavalinA in amoeba proteus. Cytochalasin B can also interact with the auxin indole-3-acetic...
Escherichia coli magnesium ion transporters such as CorA. lectins such as ConcanavalinA IMPDH and IMPDH2 Examples of heterotetramers include haemoglobin (pictured)...
protein complexes: C-reactive protein (CRP), transthyretin (TTR), and concanavalinA (Con A). This method is used to observe the unfolding degree for each of...
2012-02-01. Quiocho, F. A.; Reeke, G. N.; Becker, J. W.; Lipscomb, W. N.; Edelman, G. M. (1971). "Structure of ConcanavalinA at 4 A Resolution". Proc. Natl...
Ehwald R (1994). "Suitability of aqueous dispersions of dextran and ConcanavalinA for glucose sensing in different variants of the affinity sensor". Biosens...
It is the end product of a non-conjugated pteridine compound and inhibits the growth of lymphocytes produced by concanavalin. High levels of the chemical...
readily isolated from the seeds; the others are concanavalinA, concanavalin B, and urease. Canavalin is a vicilin protein homologous to phaseolin. The crystallization...
Affinity electrophoresis is a general name for many analytical methods used in biochemistry and biotechnology. Both qualitative and quantitative information...
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