Tafluprost information

Tafluprost
Clinical data
Trade names	Saflutan, Taflotan, Zioptan
AHFS/Drugs.com	Multum Consumer Information
Routes of; administration	Topical eye drops
ATC code	S01EE05 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Pharmacokinetic data
Metabolism	Activation by ester hydrolysis, deactivation by beta oxidation
Onset of action	2–4 hrs
Duration of action	≥ 24 hrs
Identifiers
	IUPAC name Isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate;
CAS Number	209860-87-7;
PubChem CID	6433101;
DrugBank	DB08819;
ChemSpider	8044182;
UNII	1O6WQ6T7G3;
KEGG	D06274;
ChEBI	CHEBI:66899 ;
ChEMBL	ChEMBL1963683;
CompTox Dashboard (EPA)	DTXSID401021504 ;
ECHA InfoCard	100.207.745
Chemical and physical data
Formula	C25H34F2O5
Molar mass	452.539 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)OC(=O)CCC\C=C/CC(C(O)CC1O)C1\C=C\C(F)(F)COc2ccccc2;
	InChI InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1; Key:WSNODXPBBALQOF-VEJSHDCNSA-N;

Tafluprost (trade names Taflotan by Santen Pharmaceutical, Zioptan by Merck in the US and Saflutan by Mundipharma in Australia) is a prostaglandin analogue. It is used topically (as eye drops) to control the progression of open-angle glaucoma and in the management of ocular hypertension, alone or in combination with other medication. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.^[2]^[3]

^ "Product monograph" (PDF). hres.ca. Retrieved 6 April 2024.
^ Cite error: The named reference PPA was invoked but never defined (see the help page).
^ Cite error: The named reference AC was invoked but never defined (see the help page).

[1] "Product monograph" (PDF). hres.ca. Retrieved 6 April 2024.

[PPA-2] Cite error: The named reference PPA was invoked but never defined (see the help page).

[AC-3] Cite error: The named reference AC was invoked but never defined (see the help page).

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