Loxoprofen information

Loxoprofen
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, transdermal
ATC code	M02AA31 (WHO) ;
Legal status
Legal status	JP: Class 1 OTC; BR: Red Stripe (Rx only);
Pharmacokinetic data
Protein binding	97%
Metabolism	Liver glucuronidation
Elimination half-life	75 minutes
Excretion	Kidney
Identifiers
	IUPAC name (RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid;
CAS Number	68767-14-6 ;
PubChem CID	3965;
DrugBank	DB09212 ;
ChemSpider	3828 ;
UNII	3583H0GZAP;
KEGG	D08149 ;
ChEBI	CHEBI:76172 ;
ChEMBL	ChEMBL19299 ;
CompTox Dashboard (EPA)	DTXSID1045164 ;
Chemical and physical data
Formula	C15H18O3
Molar mass	246.306 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C2C(Cc1ccc(cc1)C(C(=O)O)C)CCC2;
	InChI InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18) ; Key:YMBXTVYHTMGZDW-UHFFFAOYSA-N ;
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Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in some countries for oral administration. A transdermal preparation was approved for sale in Japan in January 2006;^[1] medicated tape and gel formulations followed in 2008 and 2010.

It was patented in 1977 and approved for medical use in 1986.^[2]

^ Daiichi Sankyo Co. (January 24, 2006). "Percutaneous Absorption-Type Analgesic and Anti-inflammatory Drug Loxonin Poultice 100mg Receives Approval for Manufacture" (Press release). Doctor's Guide Global Edition. Retrieved 2007-04-19.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 521. ISBN 9783527607495.

[1] Daiichi Sankyo Co. (January 24, 2006). "Percutaneous Absorption-Type Analgesic and Anti-inflammatory Drug Loxonin Poultice 100mg Receives Approval for Manufacture" (Press release). Doctor's Guide Global Edition. Retrieved 2007-04-19.

[Fis2006-2] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 521. ISBN 9783527607495.

Loxoprofen information

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Clinical data


AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, transdermal
ATC code	M02AA31 (WHO)
Legal status
Legal status	JP: Class 1 OTC BR: Red Stripe (Rx only)
Pharmacokinetic data
Protein binding	97%
Metabolism	Liver glucuronidation
Elimination half-life	75 minutes
Excretion	Kidney
Identifiers
IUPAC name (RS)-2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
CAS Number	68767-14-6^N
PubChem CID	3965
DrugBank	DB09212^Y
ChemSpider	3828^Y
UNII	3583H0GZAP
KEGG	D08149^Y
ChEBI	CHEBI:76172^N
ChEMBL	ChEMBL19299^Y
CompTox Dashboard (EPA)	DTXSID1045164
Chemical and physical data
Formula	C₁₅H₁₈O₃
Molar mass	246.306 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES O=C2C(Cc1ccc(cc1)C(C(=O)O)C)CCC2
InChI InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18)^Y Key:YMBXTVYHTMGZDW-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)