For Dutch pharmaceutical company, see Synthon (company).
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Hypothetical unit in retrosynthetic analysis
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J. Corey.[1] He noted in 1988 that the "word synthon has now come to be used to mean synthetic building block rather than retrosynthetic fragmentation structures".[2]
It was noted in 1998[3] that the phrase did not feature very prominently in Corey's 1981 book The Logic of Chemical Synthesis,[4] as it was not included in the index. Because synthons are charged, when placed into a synthesis an uncharged form is found commercially instead of forming and using the potentially very unstable charged synthons.
^E. J. Corey (1967). "General methods for the construction of complex molecules" (PDF). Pure and Applied Chemistry. 14: 30–37. doi:10.1351/pac196714010019. S2CID 73595158.
^E. J. Corey (1988). "Robert Robinson Lecture. Retrosynthetic thinking—essentials and examples". Chem. Soc. Rev. 17: 111–133. doi:10.1039/CS9881700111.
^W. A. Smit, A. F. Buchkov, R. Cople (1998). Organic Synthesis, the science behind the art. Royal Society of Chemistry. ISBN 0-85404-544-9.{{cite book}}: CS1 maint: multiple names: authors list (link)
^Elias James Corey; Xue-Min Cheng (1995). The logic of chemical synthesis. Wiley-Interscience. ISBN 0-471-11594-0.
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive...
single target. Synthon A fragment of a compound that assists in the formation of a synthesis, derived from that target molecule. A synthon and the corresponding...
distillation. Overall, decarboxylation depends upon stability of the carbanion synthon R− , although the anion may not be a true chemical intermediate. Alkanoic...
C1 chemistry is the chemistry of one-carbon molecules. Although many compounds and ions contain only one carbon, stable and abundant C-1 feedstocks are...
by Biolex. In May 2012 Biolex announced that it sold the LEX System to Synthon, a Netherlands-based specialty pharmaceutical company. The sale included...
reagent. It is often used as a synthetic equivalent for the phenyl "Ph−" synthon. Phenylmagnesium bromide is commercially available as solutions of diethyl...
hydrocarbons, as well as the halogenated product. Haloalkanes behave as the R+ synthon, and readily react with nucleophiles. Hydrolysis, a reaction in which water...
derivatives. With carbanions, it serves again as a source of the benzoyl cation synthon, C6H5CO+. Benzoyl peroxide, a common reagent in polymer chemistry, is produced...
organic cyanides are called nitriles. In organic synthesis, cyanide is a C-1 synthon; i.e., it can be used to lengthen a carbon chain by one, while retaining...
the malonic ester can be thought of being equivalent to the −CH2COOH synthon. The esters chosen are usually the same as the base used, i.e. ethyl esters...
functional groups have been synthesized, serving as CO2 and α-diketone synthons. Finally, Stephen G. Davies of Oxford has designed a chiral auxiliary that...
Omnic by Astellas Pharma Europe. The largest manufacturer of tamsulosin is Synthon BV (the Netherlands).[citation needed] Tamsulosin hydrochloride is marketed...
transformations. The esters of malonic acid are also used as a −CH2COOH synthon in the malonic ester synthesis. Malonic acid is the starting substrate...
These may be understood with key concepts such as the supramolecular synthon and the secondary building unit. The term 'crystal engineering' was first...
synthesis, EtBr is the synthetic equivalent of the ethyl carbocation (Et+) synthon. In reality, such a cation is not actually formed. For example, carboxylates...
Slawin, Alexandra M. Z.; Nolan, Steven P. (2010). "A Versatile Cuprous Synthon: [Cu(IPr)(OH)] (IPr = 1,3 bis(diisopropylphenyl)imidazol-2-ylidene)". Organometallics...
(September 2001). "The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of α-Amino Acid Derived Imidazolines"...
electrophilic character of this reagent and its use in introducing the equivalent synthon "CO2+": R−NH2 + COCl2 → R−N=C=O + 2 HCl, where R = alkyl, aryl Such reactions...
like the bromide analog, is a synthetic equivalent for the phenyl anion synthon. Iodobenzene reacts with chlorine to give the complex, iodobenzene dichloride...
Massachusetts Institute of Technology Known for Retrosynthetic analysis Synthon Corey–Bakshi–Shibata catalyst Corey–Chaykovsky reaction Corey–Fuchs reaction...
Dictyopterene A: Optically Active Tributylstannylcyclopropane as a Chiral Synthon". Bulletin of the Chemical Society of Japan. 73 (2): 409–416. doi:10.1246/bcsj...
in Nijmegen. Other notable companies headquartered in Nijmegen include Synthon, a Dutch multinational pharmaceutical company and Vaxxinova, an EW group...
compounds. Apart from acting as the synthetic equivalent of an ethyl anion synthon for nucleophilic addition, ethylmagnesium bromide may be used as a strong...
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