Stavudine (d4T), sold under the brand name Zerit among others, is an antiretroviral medication used to prevent and treat HIV/AIDS.[4] It is generally recommended for use with other antiretrovirals.[4] It may be used for prevention after a needlestick injury or other potential exposure.[4] However, it is not a first-line treatment.[4] It is given by mouth.[4]
Common side effects include headache, diarrhea, vomiting, rash, and peripheral nerve problems.[4] Severe side effects include high blood lactate, pancreatitis, and an enlarged liver.[4] It is not generally recommended in pregnancy.[4] Stavudine is in the nucleoside analog reverse-transcriptase inhibitor (NRTI) class of medication.[4]
Stavudine was first described in 1966 and approved for use in the United States in 1994.[5] It is available as a generic medication.[4]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Cite error: The named reference Stavudine FDA label was invoked but never defined (see the help page).
^"Zerit EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 13 October 2020.
^ abcdefghij"Stavudine Monograph for Professionals - Drugs.com". www.drugs.com. Archived from the original on 10 November 2016. Retrieved 9 November 2016.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 505. ISBN 9783527607495. Archived from the original on 8 September 2017.
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