Figure 1 Schematic representation of transmembrane proteins: 1. a membrane protein with one transmembrane domain 2. a membrane protein with three transmembrane domains 3. OAT1 is believed to have twelve transmembrane domains.[1] The membrane is represented in light brown.
The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene.[2][3][4] It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.[5]
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and 28 Related for: Organic anion transporter 1 information
the Organo AnionTransporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate...
Solute carrier organicaniontransporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. Pharmacogenomic research indicates...
Solute carrier organicaniontransporter family member 1B3 (SLCO1B3) also known as organicanion-transporting polypeptide 1B3 (OATP1B3) is a protein that...
Solute carrier family 22 member 8, or organicaniontransporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene. OAT3 is involved...
Solute carrier organicaniontransporter family member 2B1 also known as organicanion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans...
proximal tubule via the organicaniontransporter-1 and exert their diuretic action by binding to the Na(+)-K(+)-2Cl(-) co-transporter type 2 in the thick...
Solute carrier organicaniontransporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene. This gene encodes a sodium-independent...
proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier proteins than the organicaniontransporters....
Solute carrier organicaniontransporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene. Solute carrier family GRCh38: Ensembl...
Solute carrier family 22 (organicanion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the...
Solute carrier organicaniontransporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene. SLCO3A1+protein,+human at the U...
Solute carrier organicaniontransporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by...
Kanai Y, Endou H (Jul 1998). "Identification of multispecific organicaniontransporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82...
Monocarboxylate transporter1 is a ubiquitous protein that in humans is encoded by the SLC16A1 gene (also known as MCT1). It is a proton coupled monocarboxylate...
However, it was not to be transported by OCT1 POU2F1, OAT1 (organicaniontransporter1), OCT2, OATP1B3 (SLCO1B3), P-gp (P-glycoprotein), or BCRP (ABCG2)...
Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose across the plasma membrane, a process known as facilitated...
Kimura M, Kanai Y, Endou H (September 2000). "Rat multispecific organicaniontransporter1 (rOAT1) transports zidovudine, acyclovir, and other antiviral...
by the proximal tubular cells via an organicaniontransporter (OAT) in the basolateral membrane. Organicanions are secreted through the proximal tubular...
Reimer RJ, Edwards RH (2004). "Organicanion transport is the primary function of the SLC17/type I phosphate transporter family". Pflügers Arch. 447 (5):...
ATP-binding cassette transporter sub-family C member 11, also MRP8 (Multidrug Resistance-Related Protein 8), is a membrane transporter that exports certain...
are salts. Many organic compounds are chlorides. The pronunciation of the word "chloride" is /ˈklɔːraɪd/. The chlorine ion is an anion (negatively charged...
cotransporter organicanion-dicarboxylate exchanger Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3...
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