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General representation of a ProTide
The ProTide technology is a prodrug approach used in molecular biology and drug design. It is designed to deliver nucleotide analogues (as monophosphate) into the cell (ProTide: PROdrug + nucleoTIDE). This technology was invented by Professor Chris McGuigan from the School of Pharmacy and Pharmaceutical Sciences at Cardiff University in the early 1990s. ProTides form a critical part of antiviral drugs such as sofosbuvir, tenofovir alafenamide, and remdesivir.[1]
^Mehellou Y, Rattan HS, Balzarini J (March 2018). "The ProTide Prodrug Technology: From the Concept to the Clinic". Journal of Medicinal Chemistry. 61 (6): 2211–2226. doi:10.1021/acs.jmedchem.7b00734. PMC 7075648. PMID 28792763.
The ProTide technology is a prodrug approach used in molecular biology and drug design. It is designed to deliver nucleotide analogues (as monophosphate)...
general name referring to the negative ion of any hydrogen isotope (H−) Protide: 1H− Deuteride: 2H−, D − Tritide: 3H−, T − Hydrogen ions drive ATP synthase...
prodrug of tenofovir. It was developed by Gilead Sciences based on the protide technology of Chris McGuigan and is applied in the form of tenofovir alafenamide...
electronegative atoms with open lone pairs. Hydrides containing protium are known as protides. Hydrides containing deuterium are known as deuterides. Some deuterides...
barrier to the development of resistance. Sofosbuvir is a prodrug of the Protide type, whereby the active phosphorylated nucleotide is granted cell permeability...
2007.03.029 Z. P. Li, B. H. Liu. K. Arai, N. Morigazaki, S. Suda (2003): "Protide compounds in hydrogen storage systems". Journal of Alloys and Compounds...
sign of inflammation or damage to cells in the liver. Remdesivir is a protide (prodrug of nucleotide) able to diffuse into cells, where it is converted...
2007.03.029 Z. P. Li, B. H. Liu. K. Arai, N. Morigazaki, S. Suda (2003): "Protide compounds in hydrogen storage systems". Journal of Alloys and Compounds...
the immunological quantitation of proteins". In Peeters, Hubert (ed.). Protides of the Biological Fluids: Proceedings of the 11th Colloquium, Bruges, Belgium...
meconium in the detection of fibrocystic disease of the pancreas, (1968) Protides of the Biol Fluids, 16, 517–524 Hobbs, J.R., Harboe, N., Alper, C., Johansson...
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