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Mexiletine information


Mexiletine
Clinical data
Trade namesMexitil, NaMuscla
AHFS/Drugs.comMonograph
MedlinePlusa607064
License data
  • US DailyMed: Mexiletine
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth, intravenous
ATC code
  • C01BB02 (WHO)
Legal status
Legal status
  • CA: ℞-only[1]
  • UK: POM (Prescription only)
  • US: ℞-only
  • EU: Rx-only
Pharmacokinetic data
Bioavailability90%
Protein binding50–60%
MetabolismLiver (CYP2D6 and 1A2-mediated)
Elimination half-life10–12 hours
ExcretionKidney (10%)
Identifiers
IUPAC name
  • (RS)-1-(2,6-dimethylphenoxy)propan-2-amine
    OR
    2-(2-aminopropoxy)-1,3-dimethylbenzene
CAS Number
  • 31828-71-4 checkY
PubChem CID
  • 4178
IUPHAR/BPS
  • 2629
DrugBank
  • DB00379 checkY
ChemSpider
  • 4034 checkY
UNII
  • 1U511HHV4Z
KEGG
  • D08215 checkY
  • as HCl: D00639 checkY
ChEBI
  • CHEBI:6916 checkY
ChEMBL
  • ChEMBL558 checkY
CompTox Dashboard (EPA)
  • DTXSID8048446 Edit this at Wikidata
ECHA InfoCard100.046.190 Edit this at Wikidata
Chemical and physical data
FormulaC11H17NO
Molar mass179.263 g·mol−1
3D model (JSmol)
  • Interactive image
ChiralityRacemic mixture
SMILES
  • O(c1c(cccc1C)C)CC(N)C
InChI
  • InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3 checkY
  • Key:VLPIATFUUWWMKC-UHFFFAOYSA-N checkY
  (verify)

Mexiletine (INN) (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea. It works as a non-selective voltage-gated sodium channel blocker and belongs to the Class IB group of anti-arrhythmic medications.[2]

  1. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  2. ^ Canavero S, Bonicalzi V (13 October 2011). Central Pain Syndrome: Pathophysiology, Diagnosis and Management. Cambridge University Press. pp. 286–. ISBN 978-1-107-01021-5.

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Fentanyl

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quinine, ranolazine, procainamide, flecainide, phenytoin, carbamazepine, mexiletine and other anticonvulsant drugs. Physical therapy and other rehabilitative...

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Aconitum napellus

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include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine. Cardiopulmonary bypass is used if symptoms are refractory to treatment...

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Cardioversion

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Class 1b drugs lengthen phase 3 repolarization. They include lidocaine, mexiletine and phenytoin. Class Ic greatly slow phase 0 depolarization in the ventricles...

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Myotonic dystrophy

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pacemakers and non-invasive positive pressure ventilation. The medications mexiletine or carbamazepine can help relax muscles. Pain, if it occurs, may be treated...

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Pethidine

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Nitrous oxide

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Morphine

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Calcium channel blocker

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Salicylic acid

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Amlodipine

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Promethazine

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Sodium channel blocker

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prevention of ventricular fibrillation. Class Ib agents include lidocaine, mexiletine, tocainide, and phenytoin. Class Ic antiarrhythmic agents markedly depress...

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Lorazepam

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Chlorphenamine

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Heroin

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Analgesic

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Adjuvant analgesics, also called atypical analgesics, include orphenadrine, mexiletine, pregabalin, gabapentin, cyclobenzaprine, hyoscine (scopolamine), and...

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ALS

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trouble swallowing their saliva (sialorrhea). A 2017 review concluded that mexiletine is safe and effective for treating cramps in ALS based on a randomized...

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