Crystal structure of ZS-9. Blue spheres = oxygen atoms, red spheres = zirconium atoms, green spheres = silicon atoms.
Clinical data
Trade names
Lokelma
Other names
ZS-9
AHFS/Drugs.com
Monograph
MedlinePlus
a618035
License data
US DailyMed: Sodium zirconium cyclosilicate
Routes of administration
By mouth
ATC code
V03AE10 (WHO)
Legal status
Legal status
AU: S4 (Prescription only)
CA: ℞-only[1]
US: ℞-only[2]
EU: Rx-only[3]
In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability
Not absorbed
Excretion
Feces
Identifiers
IUPAC name
Silicic acid, sodium zirconium(4+) salt (3:2:1), hydrate
CAS Number
17141-74-1
DrugBank
DB14048
UNII
D652ZWF066
KEGG
D10727
Chemical and physical data
Formula
(2Na·H2O·3H4SiO4·H4ZrO6)n
Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium.[4] Onset of effects occurs in one to six hours.[4] It is taken by mouth.[4]
Common side effects include swelling and low blood potassium.[4] Use is likely safe in pregnancy and breastfeeding.[4] It works by binding potassium ions in the gastrointestinal tract which is then lost in the stool.[4][5]
Sodium zirconium cyclosilicate was approved for medical use in the European Union and in the United States in 2018.[4][3][6] It was developed by AstraZeneca.[4]
^"Summary Basis of Decision (SBD) for Lokelma". Health Canada. 23 October 2014. Archived from the original on 31 May 2022. Retrieved 29 May 2022.
^"Lokelma- sodium zirconium cyclosilicate powder, for suspension". DailyMed. 30 September 2022. Archived from the original on 5 December 2022. Retrieved 27 February 2023.
^ ab"Lokelma EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 8 January 2021. Retrieved 11 October 2019.
^ abcdefgh"Sodium Zirconium Cyclosilicate Monograph for Professionals". Drugs.com. Archived from the original on 1 August 2020. Retrieved 11 October 2019.
^Hoy SM (October 2018). "Sodium Zirconium Cyclosilicate: A Review in Hyperkalaemia". Drugs. 78 (15): 1605–1613. doi:10.1007/s40265-018-0991-6. PMC 6433811. PMID 30306338.
^"Drug Approval Package: Lokelma (sodium zirconium cyclosilicate)". U.S. Food and Drug Administration (FDA). 8 June 2018. Archived from the original on 13 April 2021. Retrieved 7 May 2020.
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