Candesartan information

Candesartan
Clinical data
Pronunciation	/ˌkændɪˈsɑːrtən/
Trade names	Atacand, others
Other names	Candesartan cilexetil
AHFS/Drugs.com	Monograph
MedlinePlus	a601033
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
ATC code	C09CA06 (WHO) ;
Legal status
Legal status	US: WARNING; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	15% (candesartan cilexetil)
Metabolism	Candesartan cilexetil: intestinal wall; candesartan: hepatic (CYP2C9)
Elimination half-life	9 hours
Excretion	Kidney 33%, faecal 67%
Identifiers
	IUPAC name 2-ethoxy-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-1,3-benzodiazole-7-carboxylic acid;
CAS Number	139481-59-7 ;
PubChem CID	2541;
IUPHAR/BPS	587;
DrugBank	DB00796 ;
ChemSpider	2445 ;
UNII	S8Q36MD2XX;
KEGG	D00522 ;
ChEBI	CHEBI:3347 ;
ChEMBL	ChEMBL1016 ;
CompTox Dashboard (EPA)	DTXSID0022725 ;
ECHA InfoCard	100.132.654
Chemical and physical data
Formula	C24H20N6O3
Molar mass	440.463 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOc2nc1cccc(C(=O)O)c1n2Cc5ccc(c3ccccc3c4nn[nH]n4)cc5;
	InChI InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29) ; Key:HTQMVQVXFRQIKW-UHFFFAOYSA-N ;
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Candesartan is an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure. Candesartan has a very low maintenance dose. Like Olmesartan, the metabolism of the drug is unusual as it is a cascading prodrug. Candesartan has good bioavailibility and is the most potent by weight of the AT-1 receptor antagonists.

It was patented in 1990 and approved for medical use in 1997.^[2]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[Fis2006-2] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495.

Candesartan information

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