RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
cytoplasm
nucleoplasm
mitochondrion
nucleus
Biological process
skeletal system development
noradrenergic neuron differentiation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cardiac ventricle formation
glial cell development
regulation of transcription, DNA-templated
limb bud formation
regulation of protein stability
sympathetic nervous system development
somatic stem cell population maintenance
glucose homeostasis
positive regulation of canonical Wnt signaling pathway
ventricular septum morphogenesis
protein stabilization
ascending aorta morphogenesis
negative regulation of cell death
mitral valve morphogenesis
positive regulation of translation
transcription, DNA-templated
neuroepithelial cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of Wnt signaling pathway
negative regulation of protein ubiquitination
heart development
pro-B cell differentiation
atrial septum primum morphogenesis
T cell differentiation
kidney morphogenesis
positive regulation of cell population proliferation
spinal cord development
positive regulation of apoptotic process
glial cell proliferation
canonical Wnt signaling pathway
positive regulation of N-terminal peptidyl-lysine acetylation
spinal cord motor neuron differentiation
cardiac right ventricle morphogenesis
neural tube formation
cellular response to glucose stimulus
endocrine pancreas development
negative regulation of cell population proliferation
positive regulation of insulin secretion
positive regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
cell differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6659
20677
Ensembl
ENSG00000124766
ENSMUSG00000076431
UniProt
Q06945
Q06831
RefSeq (mRNA)
NM_003107
NM_009238
RefSeq (protein)
NP_003098
NP_033264
Location (UCSC)
Chr 6: 21.59 – 21.6 Mb
Chr 13: 29.13 – 29.14 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000124766 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000076431 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994). "Characterization and mapping of the human SOX4 gene". Mammalian Genome. 4 (10): 577–84. doi:10.1007/BF00361388. PMID 8268656. S2CID 12096721.
^Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenetics and Cell Genetics. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.
^"Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene. This intronless gene encodes a member of the SOX (SRY-related HMG-box)...
Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and...
most other vertebrates have three members of the SoxC group. The three are Sox4, Sox11, and Sox12. These three are extremely similar to one another, more...
J (Dec 2006). "The establishment of neuronal properties is controlled by Sox4 and Sox11". Genes & Development. 20 (24): 3475–86. doi:10.1101/gad.403406...
possible Sox family member to participate in gene regulation with Oct4 – Sox4, Sox11, and Sox15 also participate, as the Sox protein is redundant throughout...
affecting primary tumor growth. miR-335 targets multiple pathways, including SOX4, MERTK, PTPRN2 and TNC, which contribute to metastasis-suppression. miR-335...
1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and...
the 5' UTR. A number of transcription factors such as FOXP1, SOX5, SOX6, SOX4, and MZF1 are likely to bind with the promoter, often acting to downregulate...
outflow tract separation of the pulmonary artery and aorta, and expression of Sox4 in cushions and myocardium. Foxp1 is also an important gene in muscle development...
regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3". Proceedings of the National Academy of Sciences of the United...
regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3". Proceedings of the National Academy of Sciences of the United...
which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms...
Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X (2006). "Ubc9 interacts with SOX4 and represses its transcriptional activity". Biochem. Biophys. Res. Commun...
can interact with other transcription factors such as Nkx2-5, Msx 1/2 and Sox4 to assist it binding to its target genes to regulate heart development and...